Risk Factors of Acute Urinary Retention in Benign Prostatic Hyperplasia Patients at Nongkhai Hospital
Keywords:
BPH, acute urinary retention, risk factorsAbstract
Background: Acute urinary retention (AUR) is a most serious complication or long-term disease
progression in patients with benign prostatic hyperplasia (BPH). Its effect on patient’s quality of life.
Research is needed to predict the risk factors of AUR in clinical practice in Nongkhai Hospital
Objective: To determine risk factors associated with acute urinary retention in patients with BPH at
Nongkhai hospital
Methodology: The data of retrospective case control study were collected from medical records and
records in HOSxP program of BPH patients who visited in out-patient urological clinic and emergency
room in Nongkhai Hospital from 1 January 2017 –31 December2019. The patients were divided in 2
groups. The study group was men who had acute urinary retention. The control group was men who
never had urinary retention during the study period.Demographic data and risk factors were collected .
The data was analyzed using univariate analysis and logistic regression analysis at 95% confidence
interval.
Results: The 693 patients were included to study. The control group were 653 patients and 40 patients
were case group. The incident of acute urinary retention rate is 19.24 per 1000 person-year. Age >72 ,
history of urinary retention, lower urinary tract infection and PSA > 4 are significant associated with
AUR by Univariate analysis. But only history of urinary retention, lower urinary tract infection and PSA >
4 are significant associated with AUR by logistic regression analysis. Adjusted odd ratios were 5.565,
3.732 and 3.636 respectively.
Consulted: History of urinary retention, lower tract urinary infection and PSA > 4 are risk factors for
acute urinary retention in BPH patients. It is useful for predicting acute urinary retention and preparing
proper management of BPH patients.
Keywords: BPH, acute urinary retention, risk factors
References
Study Group. Management of acute urinary retention: a worldwide survey of 6074 men with benign
prostatic hyperplasia. BJU Int. 2012 Jan;109(1):88-95. doi: 10.1111/j.1464-410X.2011.10430.x. Epub2011 Nov
25. PMID: 22117624; PMCID: PMC3272343
2. Muruganandham K, Dubey D, Kapoor R. Acute urinary retention in benign prostatic hyperplasia: Risk factors
and current management. Indian J Urol. 2007 Oct;23(4):347-53. doi: 10.4103/0970-1591.35050. PMID:
19718286; PMCID: PMC2721562.
3. Addepalli, Jagadeeswar& S, Balasubramanya& Francis, John &Thanneru, Karthik. (2019). A study on acute
urinary retention in patients with benign prostatic hyperplasia at a rural setup. International Surgery Journal.
6. 1772. 10.18203/2349-2902.isj20191905.
4. Mahakalkar, Chandrashekhar & Prasad, Ayushree & Kaple, Meghali & Jain, Niket & Khadatkar, Aniket & Jai
puria, Parag. (2016). Predictors of urinary retention in benign prostate hyperplasia. International Journal of
Research in Medical Sciences. 486-490. 10.18203/2320-6012.ijrms20160301.
5. Kim, E.D. The use of baseline clinical measures to predict those at risk for progression of benign prostatic
hyperplasia. CurrUrol Rep 5, 267–273 (2004). https://doi.org/10.1007/s11934-004-0049-z
6. Fong YK, Milani S, Djavan B. Natural history and clinical predictors of clinical progression in benign prostatic
hyperplasia. CurrOpinUrol. 2005 Jan;15(1):35-8. doi: 10.1097/00042307-200501000-00009. PMID: 15586028.
7. SiavashFalahatkar, Ali HamidiMadani, Ahmad Enshaei, Ehsan Kazemnejad, SeyedehSamaneh Ahmadi, Keivan
GholamjaniMoghaddam, AliakbarAllahkhah.Risk Factors for Acute Urinary Retention in Patients With
Benign Prostatic Hyperplasia From the Islamic Republic of Iran.UroTodayInt J. 2010 Dec;3(6). doi:10.3834
/uij.1944-5784.2010.12.15
8. Thomas K, Chow K, Kirby RS. Acute urinary retention: a review of the aetiology and management. Prostate
Cancer Prostatic Dis. 2004;7(1):32-7. doi: 10.1038/sj.pcan.4500700. PMID: 14999235.
9. Muruganandham K, Dubey D, Kapoor R. Acute urinary retention in benign prostatic hyperplasia: Risk factors
and current management. Indian J Urol. 2007 Oct;23(4):347-53. doi: 10.4103/0970-1591.35050. PMID:
19718286; PMCID: PMC2721562.
10. Verhamme KM, Sturkenboom MC, Stricker BH, Bosch R. Drug-induced urinary retention: incidence,
management and prevention. Drug Saf. 2008;31(5):373-88. doi: 10.2165/00002018-200831050-00002. PMID:
18422378.
11. Vela-Navarrete R, Gonzalez-Enguita C, Garcia-Cardoso JV, Manzarbeitia F, Sarasa-Corral JL, Granizo JJ.
The impact of medical therapy on surgery for benign prostatic hyperplasia: a study comparing changes in
a decade (1992-2002). BJU Int. 2005 Nov;96(7):1045-8. doi: 10.1111/j.1464-410X.2005.05735.x. PMID: 16225526.
12. McConnell JD, Bruskewitz R, Walsh P, Andriole G, Lieber M, Holtgrewe HL, Albertsen P, Roehrborn CG,
Nickel JC, Wang DZ, Taylor AM, Waldstreicher J. The effect of finasteride on the risk of acute urinary
retention and the need for surgical treatment among men with benign prostatic hyperplasia. Finasteride
Long-Term Efficacy and Safety Study Group. N Engl J Med. 1998 Feb 26;338(9):557-63. doi:10.1056/
NEJM199802263380901. PMID: 9475762.
13. Andersen JT, Nickel JC, Marshall VR, Schulman CC, Boyle P. Finasteride significantly reduces acute urinary
retention and need for surgery in patients with symptomatic benign prostatic hyperplasia. Urology. 1997
Jun;49(6):839-45. doi: 10.1016/s0090-4295(97)00185-4. PMID: 9187688.
14. Patel PM, Sweigert SE, Nelson M, Gupta G, Baker M, Weaver FM, McVary KT. Disparities in Benign Prostatic
Hyperplasia Progression: Predictors of Presentation to the Emergency Department in Urinary Retention. J
Urol. 2020 Aug;204(2):332-336. doi: 10.1097/JU.0000000000000787. Epub2020 Jan 28. PMID: 31990248.
15. Roehrborn CG. BPH progression: concept and key learning from MTOPS, ALTESS, COMBAT, and ALF-ONE.
BJU Int. 2008 Mar;101Suppl3:17-21. doi: 10.1111/j.1464-410X.2008.07497.x. PMID: 18307681.
16. Emberton M, Lukacs B, Matzkin H, Alcaraz A, Elhilali M, Vallancien G. Response to daily 10 mg alfuzosin
predicts acute urinary retention and benign prostatic hyperplasia related surgery in men with lower urinary
tract symptoms. J Urol. 2006 Sep;176(3):1051-6. doi: 10.1016/j.juro.2006.04.044. PMID: 16890690.
17. Crawford ED, Wilson SS, McConnell JD, Slawin KM, Lieber MC, Smith JA, Meehan AG, Bautista OM, Noble WR,
Kusek JW, Nyberg LM, Roehrborn CG; MTOPS RESEARCH Group. Baseline factors as predictors of clinical
progression of benign prostatic hyperplasia in men treated with placebo. J Urol. 2006 Apr;175(4):1422-6;
discussion 1426-7. doi: 10.1016/S0022-5347(05)00708-1. PMID: 16516013.
18. Roehrborn CG, McConnell JD, Lieber M, Kaplan S, Geller J, Malek GH, Castellanos R, Coffield S, Saltzman
B, Resnick M, Cook TJ, Waldstreicher J. Serum prostate-specific antigen concentration is a powerful predictor
of acute urinary retention and need for surgery in men with clinical benign prostatic hyperplasia. PLESS
Study Group. Urology. 1999 Mar;53(3):473-80. doi: 10.1016/s0090-4295(98)00654-2. PMID: 10096369.
19. Cahn DB, Ross CP, Dubowitch EP, Persun ML, Ginsberg PC, Harkaway RC. Predicting Acute Urinary Retention
in Patients with Elevated Post-Void Residuals. CurrUrol. 2015 Jul;8(2):79-83. doi: 10.1159/000365694. Epub2015
Jul 10. PMID: 26889122; PMCID: PMC4748769.
20. Emberton M, Elhilali M, Matzkin H, Harving N, van Moorselaar J, Hartung R, Alcaraz A, Vallancien G; Alf-One
Study Group. Symptom deterioration during treatment and history of AUR are the strongest predictors for
AUR and BPH-related surgery in men with LUTS treated with alfuzosin10 mg once daily. Urology. 2005
Aug;66(2):316-22. doi: 10.1016/j.urology.2005.03.024. PMID: 16098361
21. Roehrborn CG, McConnell JD, Lieber M, Kaplan S, Geller J, Malek GH, Castellanos R, Coffield S, Saltzman B,
Resnick M, Cook TJ, Waldstreicher J. Serum prostate-specific antigen concentration is a powerful
predictor of acute urinary retention and need for surgery in men with clinical benign prostatic hyperplasia.
Urology. 1999;53:473–480
22. Roehrborn CG, Boyle P, Gould AL, Waldstreicher J. Serum prostate-specific antigen as a predictor of prostate
volume in men with benign prostatic hyperplasia. Urology. 1999 Mar;53(3):581-9. doi: 10.1016/s0090-
4295(98)00655-4. PMID: 10096388.
23. Velmurugan P, Bhaskara Prakash AR, Sriram K, VenkatRamanan S, Natarajan K. Predictors of Acute Urinary
Retention in Benign Prostatic Hyperplasia - A Comparative Study in Patients with Acute Urinary Retention
and Without Retention.JMSCR. 2019 feb;7(2):899-905.doi: https://dx.doi.org/10.18535/jmscr/v7i2.157
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