Effects of Exercise Program on Peripheral Neuropathy and the Quality of Life in Patients with Ovarian Cancer Receiving Chemotherapy

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Ploenpit Thamnipa
Nanthana Thananowan
Rapepan Uppagan
Boonlert Viriyapak


          Purpose: To examine the effects of exercise program on peripheral neuropathy and the quality of life in patients with ovarian cancer receiving chemotherapy.

          Design: A quasi-experimental design.

          Method: Participants were 86 patients with ovarian cancer receiving chemotherapy at a university hospital. They were divided into a control group and a treatment group, with 43 samples for each group. Both group received standardized care while the treatment group also received the exercise program, including personal reviewing about hands and legs exercise with VDO for practicing at home, knowledge about peripheral neuropathy and self-care manual, and the toolkit for stimulating hands and legs sensation. The data were collected by using a demographic questionnaire, FACT/GOG-NTX and FACT-G before the program implementation (T0) and after receiving the program (T1 and T2). Data analyses included descriptive statistics, independent t-tests, chi-square tests, and repeated measures ANOVA.

          Main findings: There was no statistically significant difference of the mean scores on peripheral neuropathy (F = .52, p = .473) and the quality of life (F = .93, p = .477) between the study groups. However, for the intervention group, the time effects on peripheral neuropathy at T0 and T1 (mean difference = 4.64, p = .002) and at T0 and T2 (mean difference = 6.28, p < .001) were statistically significant.  

         Conclusion and recommendations: These findings imply that those patients in the intervention group had a stable degree of peripheral neuropathy at each two time points. Further research is needed to measure peripheral neuropathy at different times, i.e. every 3 weeks to help clarify the impairment pattern. Results enhanced nurses to understand and develop interventions to prevent peripheral neuropathy among patients receiving chemotherapy.


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Thamnipa, P., Thananowan, N., Uppagan, R., & Viriyapak, B. (2018). Effects of Exercise Program on Peripheral Neuropathy and the Quality of Life in Patients with Ovarian Cancer Receiving Chemotherapy. Nursing Science Journal of Thailand, 36(2), 42–53. Retrieved from https://he02.tci-thaijo.org/index.php/ns/article/view/146573
Research Papers


1. National Cancer Institute, Thailand. Hospital-based cancer registry 2015. Bangkok: Pornsup Printing; 2017. (in Thai).
2. Thananowan N, Wattanathaweekit S. Nursing care for ovarian cancer patients. In: Nanthana T, editor. Gynecological nursing textbook (Holistic). Bangkok: V. Print (1991); 2010. p.223-43. (in Thai).
3. Thamnipa P, Thananowan N. Nursing care for patients receiving chemotherapy. In: Nanthana T, editor. Gynecological nursing textbook (Holistic). Bangkok: V. Print (1991); 2010. p.309-27. (in Thai).
4. Wonders KY, Reigle BS, Drury DG. Treatment strategies for chemotherapy-induced peripheral neuropathy: potential role of exercise. Oncol Rev. 2010;4(2):117-25.
5. Josephs-Cowan C. Peripheral neuropathy in the ovarian cancer patient. J Gynecol Oncol Nurs. 2006;16(1):6-11.
6. Wilkes GM. Peripheral neuropathy. In: Yarbro CH, Frogge MH, Goodman M, editors. Cancer symptom management. 3rd ed. MA: Jones and Bartlett Publishers; 2003. p.333-58.
7. Kiser DW, Greer TB, Wilmoth MC, Dmochowski J, Naumann RW. Peripheral neuropathy in patients with gynecologic cancer receiving chemotherapy: patient reports and provider assessments. Oncol Nurs Forum. 2010;37(6):758-64.
8. Tofthagen C. Patient perceptions associated with chemotherapy-induced peripheral neuropathy. Clin J Oncol Nurs. 2010;14(3):E22-8.
9. Tofthagen C, Visovsky C, Hopgood R. Chemotherapy-induced peripheral neuropathy: an algorithm to guide nursing management. Clin J Oncol Nurs. 2013;17(2):138-44.
10. Nielsen E, Brant J. Chemotherapy-induced neurotoxicity: assessment and interventions for patients and risk. Am J Nurs. 2002;102 Suppl 4:16-9.
11. White CM, Pritchard J, Turner-Stokes L. Exercise for people with peripheral neuropathy. Cochrane Database Syst Rev. 2004 Oct 18;(4):CD003904.
12. Newton MJ. An exercise intervention for women undergoing chemotherapy for ovarian cancer: feasibility and preliminary outcomes [master’s thesis]. Queensland: Queensland University of Technology; 2010. 168 p.
13. Maryam A, Fazlollah A, Eesa M, Ebrahim H, Abbas VF. The effect of designed exercise programme on quality of life in women with breast cancer receiving chemotherapy. Scand J Caring Sci. 2010;24(2):251-8.
14. Thamnipa T, Konsue P, Therasakvichya S. Perception of symptoms and symptom management of side effects in ovarian cancer patients receiving chemotherapy. Journal of Nursing Science. 2014;32(1):28-38. (in Thai).
15. Bandura A. Self-efficacy: the exercise of control. New York: W.H. Freeman; 1997.
16. Kanokpran T, Srimoragot P, Sindhu S, Chuthapisith S. Effects of a self-regulation home-based shoulder exercise program on range of motion and functions of shoulder joints in patients post breast cancer surgery. Journal of Nursing Science. 2014;32(3):74-84. (in Thai).
17. Bunwan M, Naka K, Kong-in W. Effect of self-efficacy-enhancing program on skill and sustainability of breast self-examination among women at risk. Srinagarind Medical Journal. 2011;26(1):17-24. (in Thai).
18. Alhamss AR, El-Dien SAB, Elshaer IH. Health promotion program among breast cancer clients receiving chemotherapy in South Governorates in Gaza. European Journal of Business and Management. 2014;6(13):129-39.
19. Polit DF, Beck CT. Nursing research: principles and method. 7th ed. Philadelphia: Lippincott Williams & Wilkins; 2003.
20. Jodjum C, Pongthavornkamol K, Kusuma Na Ayuthaya S. The Effect of psycho-education program on quality of life in women with cervical cancer undergoing radiation therapy. Journal of Nursing Science. 2016;34 Suppl 1:143-55. (in Thai).
21. Calhoun EA, Welshman EE, Chang CH, Lurain R, Fishman A, Hunt TL, et al. Psychometric evaluation of the functional assessment of cancer therapy/Gynecologic Oncology Group-Neurotoxicity (Fact/GOG-Ntx) questionnaire for patients receiving systemic chemotherapy. Int J Gynecol Cancer. 2003;13(6):741-8.
22. Santisevee J. Quality of life of patients with Non Small Cell Lung Cancer (NSCLS) comparing between platinum-based plus etoposide versus paclitaxel plus carboplatin [master’s thesis]. Khon Kaen: Khon Kaen University; 2008. 154 p. (in Thai).
23. Cella DF, Tulsky DS, Gray G, Saraflan B, Linn E, Bonomi A, et al. The functional assessment of cancer therapy scale: development and validation of the general measure. J Clin Oncol.1993;11(3):570-9.
24. Ratanatharathorn V, Sirilerttrakul S, Jirajarus M, Silpakit C, Maneechavakajorn J, Sailamai P, et al. Quality of life, functional assessment of cancer therapy-general. J Med Assoc Thai. 2001;84(10):1430-42.
25. Udthachi K. Hand and leg exercise to reduce peripheral neuropathy in patients with ovarian cancer receiving chemotherapy [CD-ROM]. Bangkok: Division of Quality Development, Faculty of Medicine Siriraj Hospital, Mahidol University; 2010. (in Thai).
26. Arttumma N. Miracle hand [Internet]. Maha Sarakham: Baan Dong Mun Health Promoting Hospital; 2014 [cited 2014 Oct 1]. Available from: http://gishealth.moph.go.th/healthmap/upload/document/work_04986_230217_091832.pdf. (in Thai).
27. Borisut S, Kongin W, Naka K. The comparison of foot care knowledge program and the program of foot care knowledge integrating with coconut shell stepping on foot numbness in persons with type 2 diabetes. Journal of Nursing Science Chulalongkorn University. 2009;21(1):94-105. (in Thai).

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