Effects of Exercise Program on Peripheral Neuropathy and the Quality of Life in Patients with Ovarian Cancer Receiving Chemotherapy

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Ploenpit Thamnipa
Nanthana Thananowan
Rapepan Uppagan
Boonlert Viriyapak


          Purpose: To examine the effects of exercise program on peripheral neuropathy and the quality of life in patients with ovarian cancer receiving chemotherapy.

          Design: A quasi-experimental design.

          Method: Participants were 86 patients with ovarian cancer receiving chemotherapy at a university hospital. They were divided into a control group and a treatment group, with 43 samples for each group. Both group received standardized care while the treatment group also received the exercise program, including personal reviewing about hands and legs exercise with VDO for practicing at home, knowledge about peripheral neuropathy and self-care manual, and the toolkit for stimulating hands and legs sensation. The data were collected by using a demographic questionnaire, FACT/GOG-NTX and FACT-G before the program implementation (T0) and after receiving the program (T1 and T2). Data analyses included descriptive statistics, independent t-tests, chi-square tests, and repeated measures ANOVA.

          Main findings: There was no statistically significant difference of the mean scores on peripheral neuropathy (F = .52, p = .473) and the quality of life (F = .93, p = .477) between the study groups. However, for the intervention group, the time effects on peripheral neuropathy at T0 and T1 (mean difference = 4.64, p = .002) and at T0 and T2 (mean difference = 6.28, p < .001) were statistically significant.  

         Conclusion and recommendations: These findings imply that those patients in the intervention group had a stable degree of peripheral neuropathy at each two time points. Further research is needed to measure peripheral neuropathy at different times, i.e. every 3 weeks to help clarify the impairment pattern. Results enhanced nurses to understand and develop interventions to prevent peripheral neuropathy among patients receiving chemotherapy.

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How to Cite
Thamnipa, P., Thananowan, N., Uppagan, R., & Viriyapak, B. (2018). Effects of Exercise Program on Peripheral Neuropathy and the Quality of Life in Patients with Ovarian Cancer Receiving Chemotherapy. Nursing Science Journal of Thailand, 36(2), 42–53. Retrieved from https://he02.tci-thaijo.org/index.php/ns/article/view/146573
Research Papers


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