Main Article Content
Purpose: To synthesize quantitative studies associated with quality of life (QoL) among
diabetic men with erectile dysfunction (ED).
Design: A quantitative systematic review was conducted. Searches of PubMed, CINAHL, and
EBSCO were performed between January 2000 and September 2016. The main terms were “quality
of life” and “erectile dysfunction.” Two authors independently assessed methodological quality using
Main findings: Six quantitative studies concerned mostly with quality of life among diabetic
men with ED were included in this review. All high-quality studies reported that diabetic erectile
dysfunction (DED) had a negative impact on QoL, with increased severity of ED correlating with
a lower QoL. The QoL for diabetic men with ED was worse than that of nondiabetic men with ED.
Conclusion and recommendations: The existing high-quality scientific evidence reports that
DED has negative effects on QoL, mainly in the dimensions of psychology and social relationships.
Health care providers should actively assess erectile dysfunction in diabetic men in order to help
alleviate the negative impact of DED on QoL. Future research should focus on a causal relationship
between DED and QoL.
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Copyright Notice: Nursing Science Journal of Thailand has exclusive rights to publish and distribute the manuscript and all contents therein. Without the journal’s permission, the dissemination of the manuscript in another journal or online, and the reproduction of the manuscript for non-educational purpose are prohibited.
Disclaimer: The opinion expressed and figures provided in this journal, NSJT, are the sole responsibility of the authors. The editorial board bears no responsibility in this regard.
2. Price D. Sexual problems in diabetes. Medicine. 2014;43(1):38-40.
3. Hatzimouratidis K. Hatzichristou D. Erectile dysfunction and diabetes mellitus. Insulin. 2009;4(2):114-22. doi: 10.1016/S1557-0843(09)80020-1.
4. Thorve VS, Kshirsagar AD, Vyawahare NS, Joshi VS, Ingale KG, Mohite RJ. Diabetes-induced erectile dysfunction: epidemiology, pathophysiology and management. J Diabetes Complications.
2011;25(2):129-36. doi: 10.1016/j.jdiacomp.2010.03.003.
5. Tomlinson J, Wright D. Impact of erectile dysfunction and its subsequent treatment with sildenafil: qualitative study. BMJ. 2004;328:1037. doi: 10.1136/bmj.38044.662176.EE.
6. Asmara K, Hengky MM, Agustanti F, Tampubolon HP. Erectile dysfunction and health-related quality of life in elderly males. Universa Medicina. 2011;30(3):182-8.
7. Fatt QK. Erectile dysfunction and quality of life. In: Nunes KP, editor. Erectile dysfunction - disease-associated mechanisms and novel insights into therapy. Rijeka, Croatia: InTech; 2012. p.3-39.
8. Ishizu H, Ohnaka Y, Hongkun M, Yoshida N. Male erectile dysfunction and quality of life. Int Congr Ser.2006:1287:111-5. doi: 10.1016/j.ics.2005.11.070.
9. Mitkov MD, Aleksandrova IY, Orbetzova MM. Effects of transderma testosterone or alpha-lipoic acid on erectile dysfunction and quality of life in patients with type 2 diabetes mellitus. Folia Med (Plovdiv). 2013;55(1):55-63. doi: 10.2478/folmed-2013-0006.
10. McCabe MP, Althof SE. A systematic review of the psychosocial outcomes associated with erectile dysfunction: does the impact of erectile dysfunction extend beyond a man’s inability to have sex? J Sex Med. 2014;11(2):347–63. doi: 10.1111/jsm.12374.
11. Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009;6(7):e1000097. doi:10.1371/journal.pmed.1000097.
12. De Berardis G, Franciosi M, Belfiglio M, Di Nardo B, Greenfield S, Kaplan SH, et al. Erectile dysfunction and quality of life in type 2 diabetic patients: a serious problem too often overlooked. Diabetes Care. 2002;25(2):284-91. doi: 10.2337/diacare.25.2.284.
13. Penson DF, Latin, DM, Lubeck DP, Wallace KL, Henning JM, Lue TF, et al. Do impotent men with diabetes have more severe erectile dysfunction and worse quality of life than the general population of impotent patients? Results from the Exploratory Comprehensive Evaluation of Erectile Dysfunction (ExCEED) database. Diabetes Care. 2003;26(4):1093-9. doi: 10.2337/diacare.26.4.1093.
14. De Berardis G, Pellegrini F, Franciosi M, Belfiglio M, Di Nardo B, Greenfield S. Longitudinal assessment of quality of life in patients with type 2 diabetes and self-reported erectile dysfunction. Diabetes Care. 2005;28(11):2637-43. doi: 10.2337/diacare.28.11.2637.
15. Avasthi A, Grover S, Bhansali A, Dash RJ, Gupta N, Sharan P, et al. Erectile dysfunction in diabetes mellitus contributes to poor quality of life. Inter Rev Psychiatry. 2011;23(1):93-9. doi: 10.3109/09540261.2010.545987.
16. Brooke JC, Walter DJ, Kapoor D, Marsh H, Muraleedharan V, Jones TH. Testosterone deficiency and severity of erectile erectile dysfunction are independently associated with reduced quality of life in men with type 2 diabetes. Andrology. 2014;2(2):205-11. doi: 10.1111/j.2047-2927.2013.00177.x.
17. Malavige LS, Jayaratne SD, Kathriarachchi ST, Sivayogan S, Ranasinghe P, Levy JC. Erectile dysfunction is a strong predictor of poor quality of life in men with type 2 diabetes mellitus. Diabet Med. 2014;31(6):699-706. doi: 10.1111/dme.12412.
18. Kmet LM, Lee RC, Cook LS. Standard quality assessment criteria for evaluating primary research papers from a variety of fields. Edmonton: Alberta Heritage Foundation for Medical Research; 2004. 22 p.
19. Lee L, Packer TL, Tang SH, Girdler S. Self-management education programs for age-related macular degeneration: a systematic review. Australas J Ageing. 2008;27(4):170–6. doi: 10.1111/j.1741-6612.2008.00298.x.
20. Burns N, Grove SK. The practice of nursing research: appraisal, synthesis, and generation of evidence. 6th ed. St. Louis: Saunders/Elsevier; 2009. 768 p.
21. Hickey A, Barker M, McGee H, O’Boyle C. Measuring health-related quality of life in older patient populations. Pharmacoeconomics. 2005;23(10):971-93. doi: 10.2165/00019053-200523100-00002.
22. Kliempt P, Ruta D, McMurdo M. Measuring the outcomes of care in older people: a non-critical review of patient- based measures. Rev Clin Gerontol. 2000;10(1):33–42. doi: 10.1017/S0959259800001040.
23. Stamogiannou I, Grunfeld EA, Denison K, Muir G. Beliefs about illness and quality of life among men with erectile dysfunction. Int J Impot Res. 2005;17(2):142–7. doi: 10.1038/sj.ijir.3901220.
24. Abolfotouh MA, al-Helali NS. Effect of erectile dysfunction on quality of life. East Mediterr Health J. 2001;7(3):510-8.
25. Farahat TM, Maraee AH, Hegazy NN, Ismail IA. Quality of life in patients with erectile dysfunction in Shebin El Kom District. Menoufia Medical Journal. 2017;30(2):607-13. doi: 10.4103/mmj.mmj_474_16.