Selected Factors Related to Adherence to Intravenous Chemotherapy in Children with Acute Lymphoblastic Leukemia

Main Article Content

Chamaiporn Parkomnok
Apawan Nookong
Somsiri Rungamornrat


         Purpose: This study was aimed at studying the correlation between perception of consequences of illness, perception of control/cure, adverse drug reaction from chemotherapy, duration of treatment with chemotherapy, communication between nurses and caregivers and adherence to treatment protocol of children with acute lymphoblastic leukemia (ALL).

         Design: A correlational study.

         Methods: The subjects consisted of 93 pairs of caregivers and children with ALL aged 1-15 years who were treated with chemotherapy at two tertiary hospitals. Data were collected by using the demographic data questionnaire, the communication between nurses and caregivers questionnaire, the revised illness perception questionnaire, the medical record form for adherence to treatment protocol and adverse drug reactions. Data were analyzed by using descriptive statistics, Chi-square, and Fisher’s exact test.  

         Main findings: The findings revealed that 74.19% of children with ALL adhered to treatment protocol. Duration of treatments and communication between nurses and caregivers were correlated with adherence to treatment protocol with statistical significance (c2 = 15.559, p < .001 and 7.717, p < .01, respectively). Adverse drug reaction was correlated with adherence to treatment protocol (p < .001). Perception of consequences of illness and perception of control/cure of caregivers were not correlated with adherence to treatment protocol (c2 = 1.904, p >.05 and .009, p > .05, respectively).

         Conclusion and recommendations: Adverse drug reaction, duration of treatments and communication between nurses and caregivers were correlated with adherence to treatment protocol with statistical significance. Therefore, healthcare personnel should develop guidelines for managing adverse drug reaction from chemotherapy and improve effective communication with caregivers to promote adherence to treatment protocol of children with ALL.

Article Details

How to Cite
Parkomnok, C., Nookong, A., & Rungamornrat, S. (2020). Selected Factors Related to Adherence to Intravenous Chemotherapy in Children with Acute Lymphoblastic Leukemia. Nursing Science Journal of Thailand, 38(3), 35–49. Retrieved from
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