Factors Associated with Phosphate Binder Adherence among Patients Undergoing Hemodialysis in China
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Abstract
Purpose: To study factors associated with phosphate binder adherence among patients undergoing hemodialysis in China.
Design: Correlational predictive study.
Methods: A total of 158 participants receiving hemodialysis at two hemodialysis centers under a university in China were recruited via convenience sampling. Data were collected using Chinese version of modified Medication Adherence Report Scale (MARS), modified Beliefs about Medicines Questionnaire (BMQ), modified Health Care Climate (HCC) Scale, and Phosphate Binder Knowledge Test (PBKT). Descriptive statistics, Mann-Whitney U test, Chi-square test, and binary logistic regression were applied for statistical analysis.
Main findings: Results indicated that 54.4% of the participants did not adhere to phosphate binders. In binary logistic regression, participants with higher knowledge about phosphate binder (OR = 10.73, 95%CI = 3.84, 29.97), higher beliefs about necessity of phosphate binder (OR = 1.23, 95%CI = 1.09, 1.39), and lower concerns about phosphate binder (OR = .88, 95%CI = .79, .98) had better phosphate binder adherence.
Conclusion and recommendations: Phosphate binder adherence was poor in patients undergoing hemodialysis in China. Knowledge and beliefs about phosphate binders are crucial in improving patients’ phosphate binder adherence. Health care providers should provide efficient interventions enhancing knowledge and positive beliefs about phosphate binders in hemodialysis patients.
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References
Kidney Disease: Improving Global Outcomes (KDIGO) CKD-MBD Update Work Group. KDIGO 2017 Clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD). Kidney Int Suppl (2011). 2017;7(1):1-59. doi: 10.1016/j.kisu.2017.04.001.
Shaman AM, Kowalski SR. Hyperphosphatemia management in patients with chronic kidney disease. Saudi Pharm J. 2016;24(4):494-505. doi: 10.1016/j.jsps.2015.01.009.
Ghimire S, Castelino RL, Lioufas NM, Peterson GM, Zaidi ST. Nonadherence to medication therapy in haemodialysis patients: a systematic review. PLoS One. 2015;10(12):e0144119. doi: 10.1371/journal.pone.0144119.
Karamanidou C, Clatworthy J, Weinman J, Horne R. A systematic review of the prevalence and determinants of nonadherence to phosphate binding medication in patients with end-stage renal disease. BMC Nephrol. 2008;9:2. doi: 10.1186/1471-2369-9-2.
Schmid H, Hartmann B, Schiffl H. Adherence to prescribed oral medication in adult patients undergoing chronic hemodialysis: a critical review of the literature. Eur J Med Res. 2009;14(5):185-90. doi: 10.1186/2047-783x-14-5-185.
Umeukeje EM, Mixon AS, Cavanaugh KL. Phosphate-control adherence in hemodialysis patients: current perspectives. Patient Prefer Adherence. 2018;12:1175-91. doi: 10.2147/PPA.S145648.
Shi YX, Liu JD, Zhao Y. Effects of a nurse-led intensive education program on chronic renal failure patients with hyperphosphatemia. Zhonghua Hu Li Za Zhi. 2011;46(3):250-3. doi: 10.3761/j.issn.0254-1769.2011.03.011.
World Health Organization. Adherence to long-term therapies: evidence for action. Geneva: World Health Organization; 2003. 196 p.
Park H, Rascati KL, Lawson KA, Barner JC, Richards KM, Malone DC. Adherence and persistence to prescribed medication therapy among Medicare part D beneficiaries on dialysis: comparisons of benefit type and benefit phase. J Manag Care Spec Pharm. 2014;20(8):862-76. doi: 10.18553/jmcp.2014.20.8.862.
Chan YM, Zalilah MS, Hii SZ. Determinants of compliance behaviours among patients undergoing hemodialysis in Malaysia. PLoS One. 2012;7(8):e41362. doi: 10.1371/journal.pone.0041362.
Martins MT, Silva LF, Kraychete A, Reis D, Dias L, Schnitman G, et al. Potentially modifiable factors associated with non-adherence to phosphate binder use in patients on hemodialysis. BMC Nephrol. 2013;14(1):208. doi: 10.1186/1471-2369-14-208.
Neri L, Martini A, Andreucci VE, Gallieni M, Rey LA, Brancaccio D, et al. Regimen complexity and prescription adherence in dialysis patients. Am J Nephrol. 2011;34(1):71-6. doi: 10.1159/000328391.
Mechta Nielsen T, Frojk Juhl M, Feldt-Rasmussen B, Thomsen T. Adherence to medication in patients with chronic kidney disease: a systematic review of qualitative research. Clin Kidney J. 2018;11(4):513-27. doi: 10.1093/ckj/sfx140.
Wang Y, Liu Q. Survey of the use of phosphate binders in maintaining hemodialysis patients. Clinical Focus. 2009;3(24):234-5.
Chater AM, Parham R, Riley S, Hutchison AJ, Horne R. Profiling patient attitudes to phosphate binding medication: a route to personalising treatment and adherence support. Psychol Health. 2014;29(12):1407-20. doi: 10.1080/08870446.2014.942663.
Jamous RM, Sweileh WM, El-Deen Abu Taha AS, Zyoud SH. Beliefs about medicines and self-reported adherence among patients with chronic illness: a study in Palestine. J Family Med Prim Care. 2014;3(3):224-9. doi: 10.4103/2249-4863.141615.
Wileman V, Chilcot J, Norton S, Hughes L, Wellsted D, Farrington K. Choosing not to take phosphate binders: the role of dialysis patients' medication beliefs. Nephron Clin Pract. 2011;119(3):c205-13. doi: 10.1159/000329106.
Wileman V, Farrington K, Wellsted D, Almond M, Davenport A, Chilcot J. Medication beliefs are associated with phosphate binder non-adherence in hyperphosphatemic haemodialysis patients. Br J Health Psychol. 2015;20(3):563-78. doi: 10.1111/bjhp.12116.
Van Camp YP, Vrijens B, Abraham I, Van Rompaey B, Elseviers MM. Adherence to phosphate binders in hemodialysis patients: prevalence and determinants. J Nephrol. 2014;27(6):673-9. doi: 10.1007/s40620-014-0062-3.
Faul F, Erdfelder E, Buchner A, Lang A-GJBrm. Statistical power analyses using G* Power 3.1: tests for correlation and regression analyses. 2009;41(4):1149-60.
Umeukeje EM, Merighi JR, Browne T, Wild M, Alsmaan H, Umanath K, et al. Health care providers' support of patients' autonomy, phosphate medication adherence, race and gender in end stage renal disease. J Behav Med. 2016;39(6):1104-14. doi: 10.1007/s10865-016-9745-7.
Brislin RW. Back-translation for cross-cultural research. 1970;1(3):185-216. doi: 10.1177/135910457000100301.
Horne R. The nature, determinants and effects of medication beliefs in chronic illness [dissertation]. London: University of London; 1997. 290 p.
Jankowska-Polanska B, Uchmanowicz I, Dudek K, Mazur G. Relationship between patients' knowledge and medication adherence among patients with hypertension. Patient Prefer Adherence. 2016;10:2437-47. doi: 10.2147/PPA.S117269.
Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373-83. doi: 10.1016/0021-9681(87)90171-8.
Field A. Discovering statistics using SPSS. 3rd ed. London: Sage Publications; 2009. 856 p.