Factors Related to Health-Related Quality of Life among Postoperative Male Muscle Invasive Bladder Cancer Patients Receiving Chemotherapy in Wenzhou China

Main Article Content

Kai Fu
Khemaradee Masingboon
Niphawan Samartkit
Saifone Moungkum


Purpose: The study aimed to describe the health-related quality of life in postoperative male muscle invasive bladder cancer patients with chemotherapy, and to examine the relationships between age, symptoms, and social support with health-related quality of life among these patients.

Design: A descriptive correlation design.

Methods: Random sampling was used to recruit 106 postoperative male muscle invasive bladder cancer patients with chemotherapy from the First Affiliated Hospital of Wenzhou Medical University in China. Data were collected using 1) A demographic information questionnaire, 2) The M.D. Anderson Symptom Inventory Questionnaire, 3) The Multidimensional Scale of Perceived Social Support questionnaire, and 4) The Functional Assessment of Cancer Therapy in Bladder cancer Questionnaire. Data were analyzed using descriptive statistics and Pearson’s correlation coefficient.

Main findings: The mean score of health-related quality of life was 79.27 out of 156 (SD = 22.58). There were significant negative relationships between age and symptom with health-related quality of life (r = - .30, p < .01; r = - .77, p < .01, respectively), while social support had positive association with health-related quality of life (r = .62, p < .01). 

Conclusion and recommendations: According to the study findings, health-related quality of life was associated with age, symptoms, and social support. To enhance health-related quality of life among postoperative male MIBC receiving chemotherapy, nurses should consider patient age, reducing symptoms, and providing social support to this population.

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How to Cite
Fu, K. ., Masingboon, K., Samartkit, N. ., & Moungkum, S. . (2023). Factors Related to Health-Related Quality of Life among Postoperative Male Muscle Invasive Bladder Cancer Patients Receiving Chemotherapy in Wenzhou China. Nursing Science Journal of Thailand, 41(2), 105–117. Retrieved from https://he02.tci-thaijo.org/index.php/ns/article/view/258630
Research Papers


Saginala K, Barsouk A, Aluru JS, Rawla P, Padala SA, Barsouk A. Epidemiology of bladder cancer. Med Sci (Basel). 2020;8(1):15. doi: 10.3390/medsci8010015.

Chen X, Chen W, Zhou W, Zheng R, Deng Y, Wu X. Analysis of incidence and mortality of bladder cancer in China, 2013. China Cancer. 2018;27(2):81-5.

Health Commission of Wenzhou. The cancer profile report of Wenzhou city in 2018. Wenzhou: Health Commission of Wenzhou; 2019. Available from: http://wjw.wenzhou.gov.cn/art/2019/4/12/art_1209919_33243696.html. (in Chinese).

Gradishar WJ, Anderson BO, Abraham J, Aft R, Agnese D, Allison KH, et al. Breast cancer, version 3.2020, NCCN clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2020;18(4):452-78. doi: 10.6004/jnccn.2020.0016.

Zeng S, Li N, Wang H, Wang J, Zuo Y. Research progress on prevention and intervention of incision-related complications after orthotopic neobladder surgery for bladder cancer. Chinese Journal of Clinical Oncology. 2020;(24):637-9.

Allareddy V, Kennedy J, West MM, Konety BR. Quality of life in long‐term survivors of bladder cancer. Cancer. 2006;106(11):2355-62. doi: 10.1002/cncr.21896.

Ferrans CE, Zerwic JJ, Wilbur JE, Larson JL. Conceptual model of health-related quality of life. J Nurs Scholars. 2005;37(4):336-42. doi: 10.1111/j.1547-5069.2005.00058.x.

Wu M, Song J, Zhao J, Feng L, Zhang D. Research progress on health-related quality of life and its influencing factors in patients after total cystectomy and urinary diversion. Journal of Modern Urology. 2017;22(11):886-9.

Schmidt CE, Bestmann B, Kuchler T, Longo WE, Kremer B. Impact of age on quality of life in patients with rectal cancer. World J Surg. 2005;29(2):190-7. doi: 10.1007/s00268-004-7556-4.

Ren H, Tang P, Zhao Q, Ren G. Symptom clusters and related factors in bladder cancer patients three months after radical cystectomy. BMC Urol. 2017;17(1):65. doi: 10.1186/s12894-017-0255-x.

Zimet GD, Dahlem NW, Zimet SG, Farley GK. The multidimensional scale of perceived social support. J Pers Assess. 1988;52(1):30-41. doi: 10.1207/s15327752jpa5201_2.

Eom C-S, Shin DW, Kim SY, Yang HK, Jo HS, Kweon S, et al. Impact of perceived social support on the mental health and health‐related quality of life in cancer patients: results from a nationwide, multicenter survey in South Korea. Psycho-Oncology. 2013;22(6):1283-90. doi: 10.1002/pon.3133.

Liu X, Jiang J, Yu C, Wang Y, Sun Y, Tang J, et al. Secular trends in incidence and mortality of bladder cancer in China, 1990-2017: A joinpoint and age-period-cohort analysis. Cancer Epidemiol. 2019;61:95-103. doi: 10.1016/j.canep.2019.05.011.

Faul F, Erdfelder E, Buchner A, Lang A-G. Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods. 2009;41(4):1149-60. doi: 10.3758/BRM.41.4.1149.

Cleeland CS, Mendoza TR, Wang XS, Chou C, Harle MT, Morrissey M, et al. Assessing symptom distress in cancer patients: the M.D. Anderson symptom inventory. Cancer. 2000;89(7):1634-46. doi: 10.1002/1097-0142(20001001)89:7<1634:aid-cncr29>3.0.co;2-v.

Wang XS, Wang Y, Guo H, Mendoza TR, Hao X-S, Cleeland CS. Chinese version of the M. D. Anderson Symptom Inventory: Validation and application of Symptom measurement in cancer patients. Cancer. 2004;101(8):1890-901. doi: 10.1002/cncr.20448.

Huang L, Jiang Q, Ren W. Study on the relationship between coping style, social support and psychosomatic symptoms of cancer patients. Chinese Journal of Mental Health. 1996;10(1):160-1.

Cella DF, Tulsky DS, Gray G, Sarafian B, Linn E, Bonomi A, et al. The functional assessment of cancer therapy scale: development and validation of the general measure. J Clin Oncol. 1993;11(3):570-9. doi: 10.1200/JCO.1993.11.3.570.

Wan C, Meng Q, tang X, Zhang C, Luo J, Zhang X. Evaluation and introduction of FACT-G Chinese version of the Quality of Life scale for cancer patients. Journal of Practical Oncology. 2006;21(1):77-80.

Smith AB, Jaeger B, Pinheiro LC, Edwards LJ, Tan H-J, Nielsen ME, et al. Impact of bladder cancer on health-related quality of life. BJU Int. 2018;121(4):549-57. doi: 10.1111/bju.14047.

Mohamed NE, Diefenbach MA, Goltz HH, Lee CT, Latini D, Kowalkowski M, et al. Muscle invasive bladder cancer: from diagnosis to survivorship. Adv Urol. 2012;2012:142135. doi: 10.1155/2012/142135.

Kitamura H, Hinotsu S, Tsukamoto T, Shibata T, Mizusawa J, Kobayashi T, et al. Effect of neoadjuvant chemotherapy on health-related quality of life in patients with muscle-invasive bladder cancer: results from JCOG0209, a randomized phase III study. Jpn J Clin Oncol. 2020;50(12):1464-9. doi: 10.1093/jjco/hyaa123.

Quinten C, Coens C, Ghislain I, Zikos E, Sprangers MAG, Ringash J, et al. The effects of age on health-related quality of life in cancer populations: a pooled analysis of randomized controlled trials using the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 involving 6024 cancer patients. Eur J Cancer. 2015;51(18):2808-19. doi: 10.1016/j.ejca.2015.08.027.

Li M-Y, Yang Y-L, Liu L, Wang L. Effects of social support, hope and resilience on quality of life among Chinese bladder cancer patients: a cross-sectional study. Health Qual Life Outcomes. 2016;14:73. doi: 10.1186/s12955-016-0481-z.