Necessity of postoperative amoxicillin prescription after incision and drain of vestibular space caused from odontogenic infection: a double-blind, randomized controlled trial study
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Abstract
The objective of this study was to evaluate the therapeutic effect of amoxicillin after incision and drain for odontogenic vestibular space infection. The design of this study was a double-blind, randomized controlled trial in 88 patients, age between 11-70 years that were diagnosed with odontogenic vestibular space infection, all patients denied immunocompromised medical conditions and history of allergy to beta-lactam antibiotics. The demographic data,chief complaint and clinical appearances were recorded. Preoperative amoxicillin 1 g oral was prescribed, then incision and drain, penrose drain application and extraction were performed.Two groups were simple randomized. The first group, was blinded with pracebo drug orally 3 times a day for 5 day postoperatively. The second group, amoxicillin 500 mg orally 3 times a day for 5 day postoperatively, was prescribed. All patients were evaluated in the follow-up visits on 2nd day and 7th day. For the results, 1 of 88 patients (1.1%) had postoperative infection after treatment and no severe complication was found. Chi-square test showed that postoperative amoxicillin did not impact the results of the treatment. Therefore the necessity of postoperative amoxicillin prescription after incision and drain of odontogenic vestibular space infection is decreased, after adequate incision and drain and removal of infection cause in healthy patient.
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References
Maderrazo EG, Jameson JM. Infection and the host. In: Topazain RG, Goldberg MH, Hupp JR, editors. Oral and maxillofacial infection. 4th ed. Philadelphia: WB Saunder; 1994. p. 1-29.
Flynn TR. Principles of management of odontogenic infections. In: Miloro M, Ghali GE, Larsen PE, Waite PD, editors. Peterson’s principle of oral maxillofacial surgery. 2nd ed. London: BC decker; 2004. p. 277-94.
Cleveland J. Antimicrobial resistance and dental care: a CDC perspective. Dent Abstracts 1998;40:108-10.
Swift JQ, Gulden WS. Antibiotic therapy—managing odontogenic infections. Dent Clinic North Am 2002;46:623-33.
Wise R, Hart T, Cars O. Antimicrobial resistance is a major threat to public health. Br Med J 1998;317:609-10.
Apisarnthanarak A. Effectiveness of education and an antibiotic-control program in a tertiary care hospital in Thailand. Clin Infectious Dis 2006;42:768-75.
Flynn TR, Halpern LR. Antibiotic selection in head and neck infections. Oral Maxillofac Surg Clin North Am 2003;15:17-38.
Gutiérrez JL, Bagán JV, Bascones A, et al. Consensus document on the use of antibiotic prophylaxis in dental surgery and procedures. Av Odontoestomatol 2006;22:69-94.
Laskin DM. The use of prophylactic antibiotics for the prevention of postoperative infections. Oral Maxillofac Surg Clinic North Am 2003;15:155-60.
Capuzzi P, Montebugnoli L, Vaccaro MA. Extraction of impacted third molars: a longitudinal prospective study on factors that affect postoperative recovery. Oral Surg Oral Med Oral Pathol 1994;77:341-3.
Piecuch JF, Arzadon J, Lieblich SE. Prophylactic antibiotics for third molar surgery: a supportive opinion. J Oral Maxillofac Surg 1995;53:53-60.
Poeschl PW, Eckel D, Poeschl E. Postoperative prophylactic antibiotic treatment in third molar surgery—a necessity? J Oral Maxillofac Surg 2004;62:3-8.
Ren YF, Malmstrom HS. Effectiveness of antibiotic prophylaxis in third molar surgery: a meta-analysis of randomized controlled clinical trials. J Oral Maxillofac Surg 2007;65:1909-21.
Bentley KC, Head TW, Aiello GA. Antibiotic prophylaxis in orthognathic surgery: a 1-day versus 5-day regimen (discussion). J Oral Maxillofac Surg 1999;57:226-30.
Bentley KC, Head TW, Aiello GA. Antibiotic prophylaxis in orthognathic surgery: a 1-day versus 5-day regimen. J Oral Maxillofac Surg 1999;57:226-30.
Soong PL, Schaller B, Zix J, Iizuka T, Mottini M, Lieger O.The role of postoperative prophylactic antibiotics in the treatment of facial fractures: a randomized, double-blind, placebo-controlled pilot clinical study. Part 3:Le Fort and zygomatic fractures in 94 patients. Br J Oral Maxillofac Surg 2014;52:329-33.
Chole RA, Yee J. Antibiotic prophylaxis for facial fractures. Arch Otolaryngol Head Neck Surg 1987;113:1055-7.
Zallen RD, Curry JT. A study of antibiotic usage in compound mandibular fractures. J Oral Surg 1975;33:431-4.
Mitchell DA. A controlled clinical trial of prophylactic tinidazole for chemoprophylaxis in third molar surgery. Br Dent J 1986;160:284-6.
Wanichbancha K. Statistical analysis: statistical decision. Bangkok: Chulalongkorn University Printing; 2544.
Cryer PE. Norepinephrine and epinephrine release and adrenergic mediation of smoking-associated hemodynamic and metabolic events. New England J Med 1976; 295:573-7.
Mosely LH. Nicotine and its effect on wound healing. Plast Reconstr Surg 1978;61:570-5.
Miles AA, Miles EM, Burke J. The value and duration of defence reaction of the skin to the primary lodgement of bacteria. Br J Exp Pathol 1957;38:76-96
