Comparison between mefenamic acid and ibuprofen on gastrointestinal irritation and postoperative pain control in oral surgery patients
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Abstract
The objective was to compare the gastrointestinal irritation and analgesic efficacy of ibuprofen 400 mg and mefenamic acid 500 mg in patients with pain after dental surgery. A randomized, single-blind, active-controlled parallel study was performed. Healthy patients experiencing postsurgical pain after surgical removal of 1 or more third molars (including 1 mandibular impaction) were randomized to 2 groups to receive either ibuprofen 400 mg, or mefenamic acid 500 mg for postoperative analgesic. Outcomes included gastrointestinal (GI) irritation (primary outcome) and postoperative pain (secondary outcome) comparing between ibuprofen and mefenamic acid usage evaluated by total pain relief over 72 hours (TOPAR72),summed pain intensity difference over 72 hours (SPID72), patient’s global assessment of treatment at 6 hours (GLOBAL6) and 48 hours (GLOBAL48). TOPAR72 of GI irritation and postoperative pain evaluation were analyzed by independent t-test. SPID72, GLOBAL6 and GLOBAL48 were analyzed by Mann-Whitney U test that were executed by using SPSS. For the results,25 patients recorded a complete questionnaire and received ibuprofen 400 mg (n = 13) or mefenamic acid 500 mg (n = 12). The GI irritation (primary outcome) was not significant different between ibuprofen and mefenamic acid at p = 0.228 and p = 0.470 for TOPAR72 and SPID72. Postoperative pain (secondary outcome) was also not significant different between ibuprofen and mefenamic acid at p = 0.695 and p = 0.496 for TOPAR72 and SPID72. Moreover, there were no significant difference at p = 0.622 and p = 0.855 for GLOBAL6 and GLOBAL48 in satisfaction with ibuprofen and mefenamic acid. For conclusions, in patients with postoperative pain after dental surgery, mefenamic acid 500 mg and ibuprofen 400 mg had no different GI irritation and had equivalent analgesic effect in controlling of postoperative pain after dental surgery.
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