Birth Weight/ Placental Weight Ratios: Does the association differ between early- and late-onset preeclampsia?

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Published: Sep 30, 2019
DOI: https://doi.org/10.14456/tjog.2019.16
Keywords:
preeclampsia placenta birth weight early onset late onset

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Podjanee Phadungkiatwattana
Department of Obstetrics and Gynecology, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand
Songphol Puttasiri
Department of Obstetrics and Gynecology, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand

Abstract

Objectives:  Early- and late-onset preeclampsia (PE) may differ in pathophysiology and this can beObjectives:  Early- and late-onset preeclampsia (PE) may differ in pathophysiology and this can be reflcted in differences in birth weight/placental weight (BW/Pl) ratios. Therefore, we compared BW/Pl ratios of births with early- and those with late-onset PE.


Materials and Methods:  The retrospective descriptive study included all hospital-based singleton births of 24-43 weeks’ gestation between January 2007 and December 2016. A total of 51,940 pregnant women were divided into three groups: early-onset PE, late-onset PE, and pregnant women without PE. Birth weight/placental weight were compared among 3 groups.


Results:  The mean (± standard deviation; SD) BW/Pl ratios were signifiantly different in early-onset PE and late-onset PE compared with the control group (3.91 ± 0.93 in early-onset PE, 4.85 ± 0.91 in late-onset PE and 5.17 ± 0.90 in the control group, p < 0.001).  The factors signifiantly associated with BW/Pl ratios were race, infant gender, diabetes mellitus (DM), gestational age at delivery, early-onset PE, late-onset PE, small for gestational age (SGA) and large for gestational age (LGA). After adjustment for DM, gestational age at delivery, late-onset PE, SGA and LGA, the BW/Pl ratio was still associated signifiantly more with early-onset PE than with late-onset PE.


Conclusion:  The BW/Pl ratios of preeclamptic women differed between early- and late-onset PE, and that early-onset PE may be commonly associated with placental efficiency.  This suggests that preeclampsia consists of several different processes manifesting as a single disease. 

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How to Cite
(1)
Phadungkiatwattana, P.; Puttasiri, S. Birth Weight/ Placental Weight Ratios: Does the Association Differ Between Early- and Late-Onset Preeclampsia?. Thai J Obstet Gynaecol 2019, 27, 122-129.
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VOL. 27, NO. 3: (July - September 2019)
Section
Original Article

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