Second Trimester Genetic Amniocentesis at Secondary Center Hospital in Southern Thailand

Abstract

Objectives: To evaluate the complications and outcomes of second trimester genetic amniocentesis in singleton pregnancy for prenatal diagnosis at secondary center hospital in Southern Thailand.

Materials and Methods: This was a retrospective descriptive study including singleton pregnancy that had been performed second trimester amniocentesis for prenatal diagnosis at Phattalung Hospital between October 2007 and September 2012. The complications after the procedure, results of the diagnosis and outcomes of the pregnancy were reviewed. The data was shown in number and percentage.

Results: A total of 2,626 medical data of genetic amniocentesis in singleton pregnancies were reviewed. The most common indication was advanced maternal age (94.4%), the other indication was couple at risk of severe thalassemia (4.8%). There were chromosome abnormalities (3.3%) and severe thalassemia major (0.9%). The most common chromosome abnormality was trisomy 21 0.8% (22 cases). Other chromosome abnormalities were trisomy 13, 18 and sex chromosome (0.9%). The failure rate of culture was 1.3%. The fetal loss rate was 0.3%, which occurred within 14 days post procedure.

Conclusion: Second trimester genetic amniocentesis performed at secondary center hospital was a safe procedure with minimal complication.