The Comparative Study of The Large for Gestational Age Prevalence in Neonate of Diabetic Pregnant Women Between The Optimal and Suboptimal Glycemic Control Groups

Abstract

Objective: To compare the prevalences of LGA (large for gestational age) newborns in diabetic pregnant women between the optimal glycemic control and suboptimal glycemic control.

Materials and Methods: Total of 228 women, delivered at Ramathibodi Hospital between March 2010-December 2012, 114 women in each group, were enrolled. The medical records were reviewed for necessary data.  The primary outcome were the prevalences of LGA in both groups and the secondary outcome were the prevalences of neonatal hypoglycemia.

Results: The prevalence of LGA newborns in suboptimal controlled group was higher than in optimal controlled group (n = 33, 28.95% and n = 7, 6.14%, respectively) with the relative risk of 4.71 (95% CI; 2.18, 10.21).  The factors that found the association with LGA newborns were prepregnant BMI and types of DM.  Adjusted relative risk for both factors of the LGA in suboptiamal controlled group was 3.59 (95% CI; 1.60, 8.06 ).  The prevalence of neonatal hypoglycemia were not different.  (7.02% in suboptimal controlled group and 3.51% in optimal controlled group)

Conclusion: Suboptimal glycemic controlled pregnant women were found increase risk of LGA newborns.  The prevalence of neonatal hypoglycemia was not different.