Correlation of Creatinine Clearance Calculated by Cockcroft & Gault Equation and 24-hour Urine Collection in Gynecologic Cancer Patients

Main Article Content

Somsook Santibenjakoon
Nakarin Sirisabya

Abstract

Objective To study the correlation between creatinine clearances, calculated by Cockcroft & Gault equation, and 24-hour urine collection in gynecological cancer patients treated with carboplatin.

Materials &Methods Thirty-eight gynecological cancer patients who were treated with carboplatin at King Chulalongkorn Memorial Hospital from March 2008 to May 2009 were recruited. Creatinine clearances calculated by Cockcroft & Gault equation and 24-hour urine collection were compared. Data regarding age, height, lean body weight, and serum creatinine were also recorded.

Result The mean age of the patients was 51.1 (SD = 8.4) years. The mean serum creatinine was 0.58 (SD = 0. 12) mg/dl. The mean creatinine clearance that was calculated by Cockcroft & Gault equation was 90.2 (SD=19.0) ml/min compared to 99.5 (SD = 21.8) ml/min estimated by 24-hour urine collection. Pearson correlation coefficient (r) between creatinine clearance calculated by Cockcroft & Gault equation and 24-hour urine collection was 0.61 (p < 0.01).

Conclusion Moderate correlation between creatinine clearances calculated by Cockcroft & Gault equation and 24-hour urine collection in gynecological cancer patients was demonstrated.

Article Details

How to Cite
(1)
Santibenjakoon, S.; Sirisabya, N. Correlation of Creatinine Clearance Calculated by Cockcroft & Gault Equation and 24-Hour Urine Collection in Gynecologic Cancer Patients. Thai J Obstet Gynaecol 2012, 18, 35-42.
Section
Original Article
Author Biographies

Somsook Santibenjakoon, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330.

Nakarin Sirisabya, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330.