The Association between Herbal Substances and Endometrial Neoplasia in Thai Women with Postmenopausal Bleeding: A case-control study at Maharat Nakhon Ratchasima Hospital
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Abstract
Objectives: The purpose was to study the association of herbal-medicine users on the endometrial pathology of patients who were diagnosed with postmenopausal bleeding.
Materials and Methods: This research was a retrospective case control study conducted on 170 patients with postmenopausal bleeding who received treatment and underwent endometrial biopsy for pathological examination at Maharat Nakhon Ratchasima Hospital during September 1, 2016 to September 30, 2017. Data were collected from medical records and telephone interviews to obtain information about their baseline characteristics and history of herbal-medicine use.
Results: Regarding the age of the onset of postmenopausal bleeding, there were statistically significant differences between the two groups: patients with pathological diagnosis of endometrial neoplasia had a mean age of 59 years, which was higher than those with pathological diagnosis of other benign conditions that had a mean age of 56 years. In addition, the mean menopause age of patients with pathological diagnosis of endometrial neoplasia was 52 years, which was significantly higher than patients with pathological diagnosis of other benign conditions that had a mean menopause age of 50 years. With respect to BMI, it was evident that there was a larger number of patients with endometrial neoplasia who had a BMI of over or equal to 30kg/m2 than patients with other benign conditions, with statistical significance. After controlling for BMI and menopause age, patients with pathological diagnosis of endometrial neoplasia had 4.11 times higher rates of herbal-medicine user than patients with pathological diagnosis of other benign conditions (95% CI 1.76-9.59).
Conclusion: Patients who were diagnosed with endometrial neoplasia had 4.11 times higher rate of herbal medicine use than those with pathological diagnosis of other benign conditions after controlling for BMI and menopause age, with statistical significance.
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References
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