The Effectiveness of Sublingual Misoprostol in Reducing Operative Blood Loss during Total Abdominal Hysterectomy: A randomized controlled trial

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Published: Oct 1, 2019
DOI: https://doi.org/10.14456/tjog.2019.27
Keywords:
benign uterine diseases misoprostrol

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Tipsukon Harinsalai
Department of Obstetrics and Gynecology, Khon Kaen Hospital, Khon Kaen, Thailand
Manasicha Meckjarusnapa
Department of Obstetrics and Gynecology, Khon Kaen Hospital, Khon Kaen, Thailand
Junyaporn Rattanakosol
Department of Obstetrics and Gynecology, Khon Kaen Hospital, Khon Kaen, Thailand
Maleechat Sripipattanakul
Department of Obstetrics and Gynecology, Khon Kaen Hospital, Khon Kaen, Thailand
Thumwadee Tangsiriwatthana
Department of Obstetrics and Gynecology, Khon Kaen Hospital, Khon Kaen, Thailand

Abstract

Objective: To study the effectiveness and safety of preoperative sublingual misoprostol administration in reducing of operative blood loss during total abdominal hysterectomy (TAH).


Materials and Methods: Three hundred women with benign uterine diseases who were performed TAH at Khon Kaen Hospital from June 2017 to May 2018 were randomized into two groups: misoprostol group and placebo group. Intraoperative blood loss was analyzed.


Results: Baseline characteristics were similar between groups. There was no statistically significant difference in intraoperative blood loss between misoprostol and placebo group [228 ml (126-389) vs 240 ml (126-387), p = 0.943]. There was no significant difference in    hemoglobin difference, blood transfusion and hospital stay between groups.


Conclusion: Misoprostol could not reduce intraoperative blood loss during total abdominal hysterectomy.

Article Details

How to Cite
(1)
Harinsalai, T.; Meckjarusnapa, M.; Rattanakosol, J.; Sripipattanakul, M.; Tangsiriwatthana, T. The Effectiveness of Sublingual Misoprostol in Reducing Operative Blood Loss During Total Abdominal Hysterectomy: A Randomized Controlled Trial. Thai J Obstet Gynaecol 2019, 27, 210-215.
Issue
VOL. 27, NO. 4: (October - December 2019)
Section
Original Article

References

1. Jones HW. Abdominal Hysterectomy. Te Linde’s Operative Gynecology. 10th ed. Philadelphia, PA: Wolters Kluwer/Lippincott Williams & Wilkins 2008;727-43.
2. Harris WJ. Early complications of abdominal and vaginal hysterectomy. Obstet Gynecol Surv 1995;50:795-805.
3. Chavez NF, Stewart EA. Medical treatment of uterine fibroids. Clin Obstet Gynecol 2001;44:372-84.
4. Tang OS, Gemzell - Danielsson K, Ho PC. Misoprostol pharmacokinetic profiles, effects on the uterus and side effects. Int J Gynaecol Obstet 2007;99Suppl 2:S160-7.
5. Biswas J, Chaudhuri P, Mandal A, Bandyopadhyay SN, Dasgupta S, Pal A. Effect of a single preoperative dose of sublingual misoprostol on intraoperative blood loss during total abdominal hysterectomy. Int J Gynaecol Obstet 2013;122:244-7.
6. Panichpongpan A, Satirapod C, Likittanasombatv P, Israngura N. Preoperative Sublingual misoprostol in reducing intraoperative blood loss during abdominal hysterectomy. Thai J Obstet Gynaecol 2014;22:187-93.
7. Chai J, Hon E, Li CF, Pun TC, Yeung SB, Ho PC. A pilot study of pre-operative misoprostol in reducing operative blood loss during hysterectomy. Eur J Obstet Gynecol Reprod Biol 2011;158:72–5.