The Effectiveness of Sublingual Misoprostol in Reducing Operative Blood Loss during Total Abdominal Hysterectomy: A randomized controlled trial

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Tipsukon Harinsalai
Manasicha Meckjarusnapa
Junyaporn Rattanakosol
Maleechat Sripipattanakul
Thumwadee Tangsiriwatthana


Objective: To study the effectiveness and safety of preoperative sublingual misoprostol administration in reducing of operative blood loss during total abdominal hysterectomy (TAH).

Materials and Methods: Three hundred women with benign uterine diseases who were performed TAH at Khon Kaen Hospital from June 2017 to May 2018 were randomized into two groups: misoprostol group and placebo group. Intraoperative blood loss was analyzed.

Results: Baseline characteristics were similar between groups. There was no statistically significant difference in intraoperative blood loss between misoprostol and placebo group [228 ml (126-389) vs 240 ml (126-387), p = 0.943]. There was no significant difference in    hemoglobin difference, blood transfusion and hospital stay between groups.

Conclusion: Misoprostol could not reduce intraoperative blood loss during total abdominal hysterectomy.


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