Survival Rate of Cervical Cancer Patients According to the 2018 FIGO Staging System: A tertiary hospital based study, Vajira Hospital, Bangkok
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Abstract
Objectives: To validate survival rate of cervical cancer patients based on the revised 2018 International Federation of Gynecology and Obstetrics (FIGO) staging system.
Materials and Methods: Medical records of cervical cancer patients from 2006-2015 were reviewed. The locally-advanced patients without radiological imaging or incomplete medical records were excluded. All included patients were assigned as FIGO 2018 staging criteria.
Results: Of the 226 patients with cervical cancer analyzed. Mean age was 51 ±12 years (17-90 years). Squamous cell carcinoma was the most common cell type in 159 patients (70.4%). According to FIGO 2018 staging criteria, 81 patients (35.8%) were upstaged. The 5-year progression-free survival (PFS) of stage IB1, IB2 and IB3 were 83.3%, 90.0% and 84.2%, respectively and the 5-year overall survivals (OS) were 71.4%, 92.2% and 62.5%, respectively. The PFS and OS were not different among 3 sub-stages. The 5-year PFS of stage IIIB, IIIC1 and IIIC2 were 68.6%, 89.3% and 62.5%, respectively and the 5-year OS were 71.4%, 92.2% and 62.5%, respectively. The PFS and OS of stage IIIB and IIIC2 were not significantly different (p = 0.163 and 0.166, respectively) while survival of stage IIIC1 was significantly higher than stage IIIB (p = 0.025 and 0.017, respectively) and IIIC1 (p = 0.001 and 0.001, respectively).
Conclusion: The revised 2018 FIGO staging system for cervical cancer was useful to distinguish survival rates of patients with locally-advanced disease and distant metastasis while the survival rate of sub-stages of early-stage disease was no different. Stage III disease, para-aortic metastasis was the most impact on the survival rate.
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References
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