Accuracy of 12-hour versus 24-hour Urine Collection for Diagnosis of Preeclampsia
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Abstract
Objectives: To evaluate the accuracy of a 12-hour urine collection compared to a 24-hour urine collection for diagnosis of preeclampsia.
Materials and Methods: The diagnostic study was conducted between March and September 2020 at Maharat Nakhon Ratchasima Hospital, Thailand. The participants were pregnant women at ≥ 20 weeks of gestation composed with blood pressure ≥ 140/90 mmHg or clinically suspected preeclampsia. The participants were hospitalized for evaluation of blood and urine protein analysis. The 24-hour urine protein collection was stratified to the two 12-hour urine protein collection samples. The statistical analyses were used to analyze the accuracy of the test and determine the appropriate cut-off value of 12-hour urine protein compared with the gold standard of the 24-hour urine protein value.
Results: The study included 87 participants with 12-hour urine collection, which comprised 174 samples to compare with 24-hour urine collection. The incidence of preeclampsia was 47 patients (54%). The 12-hour urine collection included 174 samples. The appropriate cut-off value was ≥ 143 mg with sensitivity of 89.8%, specificity of 90.8%, and accuracy of 90.2% with near-perfect agreement (Cohen’s kappa 0.82). The 12-hour urine collection test offered higher accuracy than urine protein creatinine ratio and urine protein dipstick test.
Conclusion: The 12-hour urine collection provided high accuracy results and was the alternative test to diagnose preeclampsia.
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