Lidocaine Infiltration in Mesosalpinx for Reducing Operative Time in Postpartum Tubal Sterilization: A randomized, controlled trial

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Vichunee Nithiwatthanasak
Jesada Wutitammasuk


Objectives: To evaluate the efficacy and dosage of lidocaine infiltration in mesosalpinx for reducing operative time in postpartum tubal sterilization.

Materials and Methods: A randomized, double-blinded, placebo-controlled trial was conducted in 105 women at Khon Kaen Hospital between April and July 2020. The participants were randomly assigned into three groups—4 ml of 2% lidocaine, 1% lidocaine, and normal saline solution (NSS)—infiltrated in the mesosalpinx. Systemic sedative drugs were administered before the procedure in all groups. Operative time from skin incision to closure was recorded. Intra-operative, immediately and 1h post-operative pain score were evaluated.

Results: Age and BMI were not statistically different between 2% lidocaine, 1% lidocaine, NSS groups (29.00±4.54, 30.37±5.92, 31.03±5.08 yrs. and 25.08±3.14, 25.88±2.82, 26.08±2.60 kg/m2, respectively). Other baseline characteristics including postpartum duration before sterilization, parity, gestational age, and level of surgeon experience were similar across groups. Mean operative time for 2% lidocaine, 1% lidocaine, and NSS group was 17.9±6.19, 21.6±9.72, and 23.1±12.04 min. The operative time of 2% lidocaine was significantly shorter than NSS (p=0.027), and pain scores in 2% lidocaine were significantly lower than for NSS for all periods. The operative time of 1% lidocaine was not significantly different compared to NSS whereas 1% lidocaine had a significantly lower pain score only immediately and 1 h post-operation. There were no serious adverse events found.

Conclusion:  Two percent lidocaine infiltration in the mesosalpinx significantly shortened operative time and could reduce pain throughout postpartum tubal sterilization.


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