Intrapartum Maternal Capillary Blood Glucose in Diabetic Pregnancy and Risk Factors Associated with Neonatal Hypoglycemia
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Abstract
Objectives: To find an association between intrapartum maternal capillary blood glucose in diabetic pregnancy and neonatal hypoglycemia, and find the factors affected by this condition.
Materials and Methods: The study was a retrospective cohort study of 677 cases of diabetic pregnancies, delivered at Hatyai Hospital from October 2016 to September 2019. The primary outcome was to find an association between intrapartum maternal capillary blood glucose in diabetic pregnancy and neonatal hypoglycemia. The secondary outcome was to find factors that may be associated with neonatal hypoglycemia. Multiple logistic regression was used for analysis which quantifies the magnitude of association. Adjusting for covariates was done. The association was expressed as odd ratio and was interpreted as significant at p value < 0.05.
Results: From 677 cases reviewed, pregestational diabetes mellitus was 67 cases (9.90%) and gestational diabetes mellitus was 610 cases (90.10%). Neonatal hypoglycemia was recorded at 64 cases (9.45%). Following analysis, we found that a high level of capillary blood glucose of more than 110 mg/dL during intrapartum periods in diabetic pregnancy was associated with neonatal hypoglycemia (adjusted odds ratio (aOR) 2.46, 95%CI 1.40-4.32, p = 0.002). Cesarean delivery was also associated with this condition (aOR 4.04, 95% CI 2.15-7.55, p < 0.001).
Conclusion: Intrapartum capillary blood glucose levels exceeding 110 mg/dL and cesarean delivery in diabetic pregnancy were associated with neonatal hypoglycemia.
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