Cytomegalovirus infection of the Uterine Cervix: Histologic Findings in 3 HIV-Seropositive Patients

Abstract

Histologic findings of cytomegalovirus (CMV) infection of the uterine cervix in three HIV-seropositive patients are reported. The first case showed only few CMV-infected endocervical cells accompanied by minimal chronic inflammation. In the second case, many infected endocervical cells were associated with marked chronic inflammatory response. The third case was presented by a tumor-like lesion composed of marked acute and chronic inflammatory infiltration. Many infected endothelial and stromal cells were observed. There was no case of histologically diagnosed CMV infection of the cervix in HIV-seronegative patients in our hospital. Detection of CMV infection in cervical biopsy should necessitate further investigations to rule out underlying immunologic abnormality.