Randomized Controlled Trial of Intravaginal 50 mcg Miso prostol and 3 mg Dinoprostone for Cervical Ripening and Labour Induction at Term with Unfavorable Cervix
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Abstract
Objective To study the efficacy of 50 mcg misoprostol and 3 mg dinoprostone, both as intravaginal tablet for cervical ripening and labour induction.
Main outcome measures Mode of delivery, Bishop score before medication, after 6 and 12 hours of medication, treatment interval from insertion to delivery, Apgar score, maternal and neonatal complications.
Results There was no statistical difference between the two groups with regards to obstetric characteristics, pre-treatment Bishop score, 6 and 12 hours after medication. Tachysystole was significantly higher in those receiving misoprostol (P < 0.05). Induction to delivery interval, induction to oxytocin stimulation interval and oxytocin stimulation to delivery interval were significantly lower in those receiving misoprostol (P < 0.05). There was no significant difference in mode of delivery, Apgar score, hyperstimulation, neonatal and maternal complications
Conclusion Intravaginal misoprostol (50 mcg) is more effective agent for cervical ripening and labour induction than intravaginal dinoprostone tablet (3 mg). However misoprostol is associated with a significant higher prevalence of tachysystole than dinoprostone, but with no significant difference in neonatal and maternal compli cations.
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