Uterine Leiomyosarcoma : Multivariate Analysis of Survival Determinants

Abstract

Objective Our purpose was to study the relationship between clinicopathologic findings and survival of uterine leiomyosarcoma (LMS).

Subjects Thirty-four uterine LMS patients admitted between March 1984 and October 1993.

Main outcome measures Survival of the patients

Results In univariate analysis, positive prognostic factors were the age s 50 years, Caucasian race, premenopausal status, disease free interval s 6 months, mitotic activity < 10/10 high power fields, absence of abnormal mitotic figure, nuclear grades 1 or 2 and the presence of fascicular architecture. By multivariate analysis, if the patient's race was Caucasian, the histopathology of tumour showed absence of abnormal mitotic figures, or the patients had disease free interval z 6 months, the survival rate was longer.

Conclusion The Caucasian race, disease free interval z 6 months and absence of abnormal mitotic figures were independent prognostic factors for prolonged survival. The addition of chemotherapy or radiation to surgery in the primary treatment of the tumour does not seem to prolong survival.