Intracytoplasmic Sperm Injection (ICSI) : the First Reported Case of Pregnancy in Thailand

Abstract

Objective to present preliminary experience on the treatment of male factor infertility by the so-called ICSI technique, and to report the first successful ICSI pregnancy in Thailand. Design A retrospective analysis of first 12 ICSI-cycles. Setting Infertility Clinic, Chiang Mai Ram Hospital, Chiang Mai, Thailand. Subjects Ten consecutive couples with the diagnosis of male factor infertility or with previous failed fertilization in conventional IVF during August 1994 through February 1995.

Main outcome measures Fertilization and ongoing implantation and pregnancy rates.

Results From a total of 100 oocytes collected, 88 were considered mature and recruited for ICSI, 80% of which survived the procedure. Sixty-one percent of the intact ICSI-oocytes (43/70) fertilized normally (2 pronuclei) and most of them (88%) cleaved in vitro. Overall, thirty "good-looking” embryos were transferred in altogether 12 cycles and three pregnancies were obtained, giving the implantation rate of 10% and 25% clinical pregnancy rate per transfer. Consequently, two pregnancies unfortunately aborted at 6-7 weeks of gestation and one successful pregnancy which completed in a healthy preterm male baby.

Conclusion For male factor infertility, ICSI seems to be a very impressive solution with promising results.