Investigation of Maternal Immunologic Reaction to the Paternal Alloantigens in Couples with Habitual Abortions of Unknown Aetiology

Abstract

Objective To study maternal immunologic reaction to the partner's alloantigens in one way mixed lymphocyte culture.

Subjects The study group consisted of 9 couples with three or more successive spontaneous abortions without liveborn children and without known endogenous and exogenous causes of habitual abortions. The first control group comprised of 9 couples with liveborn children, while in the second one there were randomly selected 9 couples without children.

Main outcome measures Immunologic status including functional capacity of lympho cytes, T-lymphocytes response to division-disabled foreign histoincompatibility antigens of partner's lymphocytes, T-lymphocytes response to partner's alloantigens.

Results Women from study and control groups had no statistically significant differences in general immunologic status (functional capacity of lymphocytes). Women in the study group, T-lymphocytes response to stimulation by disabled partner's lymphocytes was significantly lower compared to both control groups (P < 0.05). However, immunologic reaction of women in study group to alloantigens of men from control groups did not show any significant difference compared to control groups results (P >0.05). 

Conclusion in couples with habitual abortion of unknown aetiology immunologic factors have a very important role.