The Significance of Basal Follicular Stimulating Hormone and Luteinizing Hormone of Previous Cycle in Prediction of the Outcome of In Vitro Fertilization

Abstract

Objective To determine the effect of basal follicular stimulating hormone level on day 3 of previous cycle on the ovarian response and clinical pregnancy rate in the treament of infertility by IVF-ET.

Subjects Thirty-eight infertile patients without male factor treated with IVF-ET under long protocol using GnRH agonist. Blood samples were taken on day 3 of previous cycle prior to ovarian stimulation.

Main outcome measures Numbers of ampoule of FSH and hMG, peak serum E2 , numbers of oocytes collected, and clinical pregnancy rate.

Results Numbers of ampoule of FSH and hMG used were significantly lower in high FSH group (> 8 IU/L). Clinical pregnancy rate in the low, medium, and high FSH group were 20%, 11.8%, and 0% respectively.

Conclusion The resullts suggested that a high basal serum FSH level is associated with a higher cancellation rate, a lower peak serum E2 level, lower number of oocytes retrieved and a lower clinical pregnancy rate.