The Influence of Beta-Endorphins on Gestational Dia betes Development

Abstract

The relationship between beta-endorphin and insulin secretion in preg nant women was studied by means of radioimmunoassay technique. The study was carried out by determination of beta-endorphins in peripheral blood samples of 28 pregnant women with gestational diabetes. They consisted of two subgroups:14 women with insulin-independent and 14 with insulin-dependent disease. Beta endorphin increase was found in both groups, according to the progression of gestation, significantly higher in the insulin-dependent group. Also, in the mentioned group, insulin administration caused a marked rise of beta-endorphins. Beta endorphins, inhibiting insulin secretion, can influence gestational diabetes devel opment. (Thai J Obstet Gynaecol 1993;5:15-18.)