Beta - Endorphin Level Elevation in Human Fetal and Neonatal Pancreas: A Consequence of Intrapartal Stress or the possible Existence of Pancreatic Islet Cells Autocrine Control?

Abstract

The presence of neurohormones in the human fetal and neonatal pan creas has not been systematically investigated until now. It has been found that hypoglycemia induced by insulin stimulates beta-endorphin (beta-EP) production, which is also confirmed in stressful situations. Therefore, we investigated beta-EP production and concentrations in human fetal pancreas during gestation and in the immediate neonatal period. Methodology of beta-EP determination was based on its concentrations evaluation in the membranes and cytosol of the pancreas cell substrate using radioimmunoassay. Results indicate that beta-EP production in pancreas exists, with concentrations rising concomitantly with gestational progres sion and in the stressful intrapartal period. According to our opinion, beta-EPs are incorporated in the endocrine regulation of pregnancy and delivery. (Thai J Obstet Gynaecol 1993;5:19-24.)