Effects of Caffeine Dose on Bowel Function Recovery Following Gynecologic Cancer Surgery: A randomized double-blind controlled trial
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Abstract
Objectives: To compare the effects of different caffeine doses on bowel function recovery following abdominal gynecological cancer surgery.
Materials and Methods: A randomized double-blind controlled trial was undertaken. 92 patients were enrolled and allocated to one of two groups: with group 1, 50 mg caffeine (n = 46) or group 2, 100 mg caffeine (n = 46). Both groups being prescribed three times a day in the postoperative period. Surgical staging had been performed on patients who were diagnosed with endometrial, ovarian, and cervical cancer. The primary outcome was to compare the time to first flatus after surgery between patients of each group. The secondary outcomes were to determine the time to first defecation, time to normal bowel movement and time to tolerate a solid diet.
Results: The mean time to first flatus was 36.54 vs 38.39 hours (p = 0.53), time to first defecation was 66.65 vs 67.08 hours (p = 0.92) and time to normal bowel sound was 26.61 vs 29.41 hours (p = 0.16). All of the results in both groups were not significantly shorter in the 100 mg caffeine group than in the 50 mg caffeine group. Furthermore, 15.22% in the 100 mg caffeine group experienced insomnia compared to 2.17% in 50 mg caffeine group (p = 0.03).
Conclusion: Drinking coffee with 50 mg of caffeine after abdominal gynecological cancer surgery did not affect bowel function recovery than 100 mg caffeine. However, it caused fewer adverse effects that could be used as additional treatment in postoperative care.
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