The Effect of Hyoscine Butylbromide for Shortening the Active Phase of the First Stage of Labor: A randomized, double-blind, placebo-controlled trial
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Abstract
Objectives: To study the efficacy and safety of hyoscine butylbromide for shortening the active phase of the first stage of labor.
Materials and Methods: After receiving informed consent, singleton pregnant women who planned vaginal delivery at Khon Kaen Hospital between July 2022 and April 2023 were randomly allocated into two groups: the control group (n = 61) received 1 mL (20 mg) of intravascular hyoscine butylbromide, while the control group (n = 61) received 1 mL of intravascular normal saline at 5-6 cm cervical dilatation. The duration of the active phase of the first stage of labor and adverse events were analyzed.
Results: Baseline characteristics were not statistically different between groups. Hyoscine butylbromide significantly shortened the active phase of the first stage of labor compared to the control group (88.5 ± 66.7 min vs 188.5 ± 101.9 min, respectively, mean difference -100.02 min (95% confidence interval -130.72 to -69.31, p <0.001)). There were no significant maternal or neonatal adverse outcomes.
Conclusion: Hyoscine butylbromide effectively shortened the active phase of the first stage of labor.
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