Prevalence of Endometrial Cancer in Patients with Endometrioid Intraepithelial Neoplasia (EIN) Histology
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Abstract
Objective - This study aims to determine the prevalence of concurrent endometrial cancer in the patients who had Endometrioid Intraepithelial Neoplasia (EIN) histology obtained from endometrial biopsy tissues.
Materials and Methods - This retrospective study recruited all patients diagnosed with EIN obtained through endometrial biopsy that was collected from endometrial sampling, fractional curettage, or hysteroscopic biopsy from the year 2015 to 2019. The demographic information and the final pathology following their hysterectomy specimens were gathered to evaluate the concurrent endometrial cancer. In the non-surgical group, they would be categorized as having no concurrent cancer if the follow-up period was up to 12 months and there was no malignancy found. Multivariable logistic regression analysis was used to evaluate the association between demographics and clinical factors with concurrent endometrial cancer.
Results - 130 EIN patients were enrolled. The mean age was 47.02 (SD = 13.2) years for those diagnosed with concurrent endometrial cancer and 52.23 (SD = 10.9) years for those who were not diagnosed with endometrial cancer. Prevalence of concurrent endometrial cancer in EIN was 23.1%, (95% confidence interval, 16.1 to 31.2). All concurrent endometrial cancer patients were diagnosed with uterine confined disease. There were no diagnoses of stage III or IV of disease.
Conclusion - one-fourth of the patients diagnosed with EIN from endometrial sampling had concurrent endometrial cancer. All patients diagnosed with concurrent endometrial cancer had the uterine confined disease. We recommend to use these data for counselling the patients who have EIN in both surgical and conservative cases.
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