Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Levels in the Neonatal Cord Blood and the Serum of Parturients Who Received Coronavirus Vaccine during Pregnancy at Venerable Thawisak Jutindharo Hospital
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Abstract
Objective: To evaluate the spike Ab level in the neonatal umbilical cord blood and serum of mothers vaccinated against coronavirus disease 2019 (COVID-19) during pregnancy and the association between the duration from the last vaccine dose to delivery and the spike Ab level.
Material and Method: This study included 75 pregnant women who were vaccinated against COVID-19 (Sinovac, Sinopharm, Astrazeneca, Pfizer, Moderna). Maternal serum and cord blood samples at delivery were collected and analyzed. Then, the association between the duration from the last vaccine dose to delivery and the spike Ab level was analyzed.
Results: Among the participants, 66 (88.0%) and 9 (12.0%) women received two and three COVID-19 vaccine doses, respectively. Spike Ab was detected in the maternal serum and umbilical cords. The median maternal spike Ab level was 2,134.0 (501–5,044) U/mL, and the median umbilical cord spike Ab level was 2,573.0 (791–8,258) U/mL. The duration from the last vaccine dose to delivery was significantly correlated with spike Ab levels in the umbilical cord. Pregnant women who received their last vaccine dose during the third trimester of pregnancy had a higher spike Ab level in the maternal serum and neonatal umbilical cords than those vaccinated in the first and second trimester of pregnancy.
Conclusions: COVID-19 vaccination during pregnancy can transfer antibody to newborn. The shorter duration of last dose of vaccination to delivery, the higher cord blood antibody.
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