Efficacy of intravenous dextrose-containing fluid in reducing labor duration of pregnant women: A randomized controlled trial
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Abstract
Objectives: To evaluate the efficacy of dextrose-containing intravenous fluid and normal saline intravenous fluid in reducing labor duration in pregnant women
Materials and methods: In this randomized controlled trial, 164 low-risk term singleton pregnant women with gestational age of 37-42 weeks presenting with labor pain at Sanpasitthiprasong Hospital were equally randomized to receive either 1) dextrose-containing intravenous fluid (5%D/N/2) or 2) normal saline (NSS) at a rate of 120ml/hr. Primary outcome was total labor time, defined as duration during active phase plus second stage. Duration of latent phase, active phase, first stage and second stage of labor and maternal and neonatal outcomes were also assessed.
Results: Demographics, gestational age, cervical dilatation at the time of randomization and augmentation were comparable between the two treatment groups. Total labor time was significantly shorter in dextrose group than NSS group (median of 177.0 (IQR 110.0, 258.0) and 206.5 (138.5, 298.3), P=0.033). Active phase duration was significantly shorter in dextrose group (median of 160.0 (100.0, 240.0) and 187.5 (127.3, 281.3), P=0.029). There was no difference in latent phase, second stage, and third stage duration. Rates of cesarean delivery and maternal complications were comparable between the two groups. Transient tachypnea of the newborn was significantly higher in NSS group than dextrose group (29.3% and 9.8%, P=0.002). There was no between-group difference in neonatal outcomes including birthweight, Apgar score, and neonatal hypoglycemia.
Conclusion: Dextrose-containing intravenous fluid administered during intrapartum may shorten total labor time especially active phase duration, without increasing maternal and neonatal complications.
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