Anomalies Detected in Third Trimester – A prospective descriptive study
Main Article Content
Abstract
Objectives: To detect the incidence of structural anomalies diagnosed by third trimester ultrasound after a normal anomaly scan and classify them according to major organ systems and types.
Materials and Methods: It was a prospective descriptive study of antenatal women who had a negative second trimester anomaly screening with a newly detected fetal anomaly in the routine third trimester ultrasound conducted in the Department of Obstetrics and Gynaecology of Government Medical College, Kozhikode over a period of 18 months from September 2020 to February 2022. These women were followed-up till delivery and neonatal outcomes were measured.
Results: The incidence of congenital anomalies detected in third trimester was 0.7% (110 cases in 15,560 deliveries). Majority of them were of urogenital system (32.7%) followed by cardiovascular system (21.8%). Commonest anomaly detected was hydronephrosis, followed by congenital diaphragmatic hernia, ventricular septal defect, ventriculomegaly and corpus callosal agenesis.
Conclusion: The ultrasound examination of third trimester is of additional benefit and can detect previously undiagnosed fetal anomalies especially development dependant anomaly like agenesis of corpus callosum and progressing anomalies like gastrointestinal and skeletal anomaly. This can help in subsequent management including counselling of parents, planning of place, time, mode of delivery and also to plan neonatal interventions.
Article Details

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
Vikram D, Pushpa C. Congenital malformations in rural Maharashtra. Indian Pediatr 2000;37:998-1001.
Alfirevic Z. Failure to diagnose a fetal anomaly on a routine ultrasound scan at 20 weeks. Ultrasound Obstet Gynecol 2005;26:797–8.
Schramm T, Gloning KP, Minderer S, Daumer-Haas C, Hörtnagel K, Nerlich A, et al. Prenatal sonographic diagnosis of skeletal dysplasias. Ultrasound Obstet Gynecol 2009;34:160-70.
Ficara A, Syngelaki A, Hammami A, Akolekar R, Nicolaides KH. Value of routine ultrasound examination at 35–37 weeks’ gestation in diagnosis of fetal abnormalities. Ultrasound Obstet Gynecol 2020;55: 75-80.3
Manegold G, Tercanli S, Struben H, Huang D, Kang A. Is a routine ultrasound in the third trimester justified?–Additional fetal anomalies diagnosed after two previous unremarkable Ultrasound examinations. Ultraschall Med 2011;32:381-6.
Gonzalez-Aguero R, Oros D, Tajada M, Sobreviela M, Sanz A, Ernesto F. Splement: Abstracts of the 24th World Congress on Ultrasound in Obstetrics and Gynecology, Barcelona, Spain. Ultrasound Obstet Gynecol 2014;44:14-17.
Drukker L, Cavallaro A, Salim I, Ioannou C, Impey L, Papageorghiou AT. How often do we incidentally find a fetal abnormality at the routine third-trimester growth scan? A population-based study. Am J Obstet Gynecol 2020;223:919-e1.
Shipp TD, Nguyen HT, Bromley B, Lyons JG, Benacerraf BR. Importance of renal abnormalities first identified in the third trimester after normal findings on a detailed second trimester structural fetal survey. J Ultrasound Med 2011;30:1567-72.
Yinon Y, Katorza E, Nassie DI, Ben-Meir E, Gindes L, Hoffmann C, Lipitz S, Achiron R, Weisz B. Late diagnosis of fetal central nervous system anomalies following a normal second trimester anatomy scan. Prenat Diagn 2013;33:929-34.
Vijaykumar M, Shailaja M, Nilofar M, Kulkarni N. Detection of structural fetal anomalies in third trimester which usually remains undetected in second trimester. Int J Applied Res 2017;3:158-62
Camara S, Fall M, Mbaye PA, Wese SF, Lo FB, Oumar N. Congenital malformations of the gastrointestinal tract in neonates at aristide le dantec university hospital in Dakar: Concerning 126 cases. Afr J Pediatr Surg 2022;19:133.
Chukwu J, Iro C, Donoghue V, McCallion N, Murphy JF, Quinn F, et al. Congenital diaphragmatic hernia: neonatal outcomes following referral to a paediatric surgical centre. Irish Med J 2009;102:260-1.
Desai N, Desai A. Congenital anomalies, a prospective study at Bombay hospital. Bombay Hosp J 2006; 48:442-5.
Taksande A, Vilhekar K, Chaturvedi P, Jain M. Congenital malformations at birth in Central India: A rural medical college hospital based data. Indian J Hum Genet 2010;16:159.
Thaddanee R, Patel HS, Thakor N. A study on incidence of congenital anomalies in newborns and their association with maternal factors: a prospective study. Int J Contemp Pediatr 2016;3:579-82.
Wills V, Abraham J, Sreedevi NS. Congenital anomalies: the spectrum of distribution and associated maternal risk factors in a tertiary teaching hospital. Int J Reprod Contracept Obstet Gynecol 2017;6: 1555-61.
Daizy NG, Pradhan A. Clinical profile of neonates with congenital malformation born at a tertiary teaching hospital in a Himalayan state of India. Int J Contemp Pediatr 2019;6:87-94.
Mohammed YA, Shawky RM, Soliman AS, Ahmed MM. Chromosomal study in newborn infants with congenital anomalies in Assiut University hospital: Cross-sectional study. Egypt J Med Hum Genet 2011;12: 79-90.