Correlation between Uterine Fibroid Volume and Vitamin D Level in Thai Women: A cross-sectional study
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Abstract
Objective: This study aimed to investigate the correlation between serum vitamin D levels and myoma uteri volume in Thai women.
Materials and Methods: This study enrolled ninety Thai women diagnosed with uterine leiomyoma. We used pelvic ultrasound to measure the total myoma volume and collected blood samples on the same day to assess serum vitamin D levels. The correlation between vitamin D levels and myoma uteri volume was then analyzed. We measured the myoma volume using the formula of width x length x height x 0.523. Vitamin D level was measured by electrochemiluminescence immunoassay.
Results: The median volume of myoma uteri was 24.57 cm³ (max = 1946.03, min = 1.05). The median serum vitamin D level was 20.35 ng/mL (max = 46, min = 7.50). The study found a weak inverse correlation between serum vitamin D levels and myoma uteri volume, although the correlation coefficient indicated a low correlation (Pearson correlation coefficient, r = - 0.239; P-value = 0.023). The prevalence of vitamin D deficiency in Thai women in the study was 48.9%.
Conclusion: Serum vitamin D levels are weakly and inversely correlated to the myoma uteri volume among Thai women.
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