The Efficacy of Oral Ginger Powder in Prevention of Postoperative Ileus after Benign Gynecologic Hysterectomy: A randomized controlled trial
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Abstract
Objectives: To assess the efficacy of oral ginger powder for prevention of postoperative bowel ileus in benign gynecologic abdominal hysterectomy.
Materials and Methods: A randomized, double-blind, placebo-controlled trial was conducted. Benign gynecologic patients who underwent abdominal hysterectomy were allocated into two groups: the experimental group received oral ginger capsules, and the control group received placebo capsules. Postoperative bowel ileus was measured by using time to first flatus as a primary outcome.
Results: Fifty-six patients were randomized to the ginger group (n = 28) and the placebo group (n = 28). The ginger group had significantly less time to first flatus than the control group (29.5 ±10.0 vs 38.9 ±8.6 hours, mean difference (MD) 9.31 hours, 95% confidence interval (CI) 4.2-14.3, p < 0.001). The ginger group also had significantly less time to first defecation than the control group (45.8 ±9.1 vs 58.5 ±14.7 hours, MD 12.6 hours, 95%CI 4.5-20.8, p = 0.003). According to the Kaplan-Meier graph, the median time to first flatus (50%) of the ginger group was 26.5 hours (95%CI 21.1-32.5) and that of the control group was 39.33 hours (95%CI 31.7- 44.7) (p = 0.007). Median time to defecation (50%) of the ginger group was 44.7 hours (95%CI 42.0-47.6) and that of the control group was 59.7 hours (95%CI 51.7-64.7) (p = 0.012). No serious adverse effects were reported.
Conclusion: Oral ginger powder could reduce postoperative bowel ileus in benign gynecologic abdominal hysterectomy.
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