The Efficacy of Oral Ginger Powder in Prevention of Postoperative Ileus after Benign Gynecologic Hysterectomy: A Randomized Controlled Trial
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Abstract
Objective: To assess the efficacy of oral ginger powder for prevention of postoperative bowel ileus in benign gynecologic abdominal hysterectomy.
Materials and Methods: A randomized, double-blind, placebo-controlled trial was conducted. Benign gynecologic patients who underwent abdominal hysterectomy were allocated into two groups: the experimental group received oral ginger capsules, and the control group received placebo capsules. Postoperative bowel ileus was measured by using time to first flatus as a primary outcome.
Results: Fifty-six patients were randomized to the ginger group (n=28) and the placebo group (n=28). The ginger group had significantly less time to first flatus than the control group (29.5±10.0 vs 38.9±8.6 hours, mean difference (MD) 9.31 hours, 95% CI 4.2-14.3, p <0.001). The ginger group also had significantly less time to first defecation than the control group (45.8±9.1 vs 58.5±14.7 hours, MD 12.6 hours, 95% CI 4.5-20.8, p=0.003). According to the Kaplan-Meier graph, the median time to first flatus (50%) of the ginger group was 26.5 hours (95%CI: 21.1 to 32.5) and that of the control group was 39.33 hours (95%CI: 31.7 to 44.7) (p=0.007). Median time to defecation (50%) of the ginger group was 44.7 hours (95%CI: 42.0 to 47.6) and that of the control group was 59.7 hours (95%CI: 51.7 to 64.7) (p=0.012). No serious adverse effects were reported.
Conclusion: Oral ginger powder can reduce postoperative bowel ileus in benign gynecologic abdominal hysterectomy.
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