Effectiveness of Preoperative Oral Diazepam for Reducing Anxiety during Loop Electrosurgical Excision Procedure: A double-blind randomized controlled trial
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Abstract
Objectives: To compare the pre- and postoperative anxiety score by State-Trait Anxiety Inventory (STAI) and visual analogue scale of anxiety (VAS-A) of the patients who received preoperative oral diazepam with those who received a placebo during loop electrosurgical excision procedure (LEEP).
Materials and Methods: This study is a double-blind, randomized controlled trial. There were 156 patients enrolled and allocated; group 1 received an oral diazepam 10 mg (n = 78) and group 2 received a placebo (n = 78) 1 hour before the operation. Both groups had received the same local anesthesia and standard care. Pre- and postoperative anxiety were measured by STAI and VAS-A immediately before the operation and, again, one hour after the operation. Pain score was measured by visual analogue scale of pain 30 minutes after the operation. All anxiety and pain scores were compared for both groups using an unpaired t test.
Results: The baseline characteristics were similar between groups. The preoperative diazepam and placebo group had STAI scores of 45.60 versus 44.02, respectively with the mean difference -1.57 (95% confidence interval -4.36,1.20) without a significant difference. Also, the postoperative anxiety score, pain score, heart rate and mean arterial pressure were not significantly different.
Conclusion: Preoperative oral diazepam 10 mg administered one hour before operation did not decrease the pre- and postoperative anxiety or pain levels in LEEP. Other treatments are required and should be the subject of further studies.
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