The Association between Preoperative Body Mass Index and Survival Outcome in Endometrial Cancer
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Abstract
Objectives: This research examined the predictive value of preoperative body mass index (BMI) for progression-free survival (PFS) and overall survival (OS) of endometrial cancer (EC) patients, as well as the correlation between BMI and surgical outcomes.
Materials and Methods: EC patients who had surgery between January 2016 and October 2022 were retrospectively analyzed. Survival rates, surgical specifics, and clinicopathological features were evaluated. Survival studies employed Cox proportional hazards models and Kaplan-Meier curves.
Results: Of 252 EC patients studied, 31% were obese (BMI ≥ 30 kg/m2). In obese individuals, endometrioid G1 histology and early-stage disease were favorable clinicopathological characteristics. Most obese people were not given adjuvant therapy. Obese individuals had a lessened paraaortic lymphadenectomy frequency. Adjuvant radiation treatment and an Eastern Cooperative Oncology Group performance level of 1 were the only significant predictors of PFS in the multivariate analysis. Age, advanced stage, histology, and surgical quality predicted OS. Patients with BMI < 30 and ≥ 30 kg/m2 showed comparable PFS, per Kaplan–Meier curves. Obese individuals had a slightly higher 5-year OS rate.
Conclusion: EC patients’ preoperative BMI affects surgical care and results. Technical difficulties during surgery reduce the frequency of full staging in obese individuals. BMI did not affect PFS, however, it may preserve OS in EC patients.
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