Maternal Factors Associated with Early Onset Neonatal Sepsis in Preterm newborns at Maharat Nakhon Ratchasima Hospital
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Abstract
Objective: To investigate maternal factors associated with early-onset neonatal sepsis in preterm infants at Maharat Nakhon Ratchasima Hospital.
Materials and Methods: This retrospective case-control study included singleton preterm neonates born at Maharat Nakhon Ratchasima Hospital between gestational ages of 24–36+6 weeks, from 2021 to 2023, totaling 497 cases. The study population consisted of 166 preterm neonates diagnosed with early-onset neonatal sepsis (EONS) and 331 preterm neonates without sepsis (case-control ratio 1: 2). Maternal demographic and clinical data were obtained from medical records. Descriptive statistics summarized baseline characteristics, while multiple logistic regression model identified maternal factors associated with EONS. Associations were reported as odds ratio (OR) with 95% confidence intervals (CI), with p < 0.05 considered statistically significant.
Results: Maternal factors significantly associated with EONS included gestational age less than 34 weeks (OR 2.77, 95%CI 1.74–4.40, p < 0.001), chorioamnionitis (OR 3.33, 95%CI 1.21–9.17, p = 0.02), maternal white blood cell count greater than 15,000 cells/µL (OR 1.92, 95%CI 1.16–3.20, p = 0.012).
Conclusion: Gestational age < 34 weeks, maternal chorioamnionitis, and maternal leukocytosis were significant risk factors associated with EONS in preterm neonates. Awareness of these factors may help in early recognition and clinical management.
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