Preeclampsia and Pregnancy outcome in Pregnant Women with Gestational Hypertension at Chonburi Hospital
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Abstract
Objective: To determine the incidence of preeclampsia (PE) and pregnancy outcome in women diagnosed with gestational hypertension (GH) at Chonburi Hospital.
Material and Method: This combined retrospective-prospective cohort study collected the data of pregnant women diagnosed GH between January, 2019 and April, 2025. Pregnant women with chronic hypertension, abortion, or multifetal gestation were excluded. The data predicting for progression from GH to PE were analyzed by logistic regression analysis.
Results: 238 pregnancies with GH were enrolled and followed until delivery. 12 of these (5.0%) were loss follow up or delivery at other hospital. 58 pregnant women (25.7%; 95% CI, 20.10-31.88%) developed preeclampsia, and 38 of these cases (16.8%; 95% CI, 8.39-17.41%) were classified as having severe features. Logistic regression reveals that the patient diagnosed with GH before 34 weeks had a higher risk of developing PE (Adjusted OR 3.30; 95% CI, 1.65-6.61). Additionally, women with DBP ≥100 mmHg at diagnosis also had a higher risk of PE progression (Adjusted OR 3.16; 95% CI, 1.58-6.34). The pregnant women with PE progression had higher rate of C-section (RR 1.69; 95% CI, 1.44-1.98), early preterm birth (RR 8.69; 95% CI, 1.80-41.86), late preterm birth (RR 5.07; 95% CI, 2.66-9.65) and low birth weight (RR 4.34; 95% CI, 2.37-7.97).
Conclusion: PE progression occurred for a quarter number in GH pregnant women. The risks of PE progression are early gestational age of GH diagnosis and high diastolic blood pressure at diagnosis. Adverse pregnancy outcomes in preeclampsia women are preterm delivery and high cesarean section rate.
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