Predictors of Success with Single-dose Methotrexate Regimen for the Treatment of Ectopic Pregnancy in Chonburi Hospital

Abstract

Objective:      To determine the factors that effect the success in management of tubal pregnancy with single–dose methotrexate regimen in Chonburi hospital.

Research design:       Retrospective descriptive study

Material and method:            Out-Patient Department (OPD) and In-Patient Department (IPD) charts of the patients who were diagnosed ectopic pregnancy and treated with methotrexate from January 2010 to December 2014 were reviewed from Chonburi hospital database. The successful treatment was defined in case of disease resolution without surgery.

Result:            For all 70 patients were enrolled in this study. The overall success rate was 88.57% (62/70). The baseline characteristics of patients were not different between success and failure group and included age, BMI, parity gestational age, pretreatment serum β-hCG and average sized of adnexal mass. The absent fetal heart activity (OR 23.12, 95%CI 1.46-366.12, p 0.02) and size of adnexal mass less than 3.5 cms (OR 37.56, 95%CI 2.49-567.62, p 0.01) were  independent predictors for successful treatment of ectopic pregnancy after analyzed with logistic regression model.

Conclusion:    The independent predictors of success in treatment of tubal pregnancy with single dose methotrexate regimen were absence of fetal heart activity and adnexal mass less than 3.5 cms.