Effect of DMPA on IL-1 Alpha in Serum of Women with Endometrioma

Abstract

Objective: The aim of this paper was to study effect of DMPA on serum IL-1α in women with endometrioma undergoing the conservative surgery.

Materials and Methods: A randomized clinical trial was performed in thirty-five women with endometrioma who underwent conservative surgery in Reproductive Endocrinology and Laparoscopy clinic in Department of Obstetrics and Gynecology, Faculty of Medicine Ramathibodi Hospital. These patients were randomly assigned to one of the following treatment: group A surgery and postoperative treatment with DMPA 150 mg intramuscular or group B surgery alone.

Results: There were no statistically significant difference in IL-1α serum level in both groups at 2 weeks or 12 weeks after surgery (P value 0.23, 1.00 respectively). There were no statistically significant difference in IL-1α level at pre and postoperation with or without DMPA postoperative treatment (P value 0.06, 0.06, 0.86 respectively). Pain score of both group  were significantly decreased at 2 weeks and 12 weeks after surgery (P value < 0.001). We found less pain score in DMPA group and the difference were statistically significant  at 12 weeks after surgery (P value 0.01).

Conclusion: The current study demonstrated that no significant change of IL-1α serum level in women with endometrioma before and after surgery, with or without postoperative treatment with DMPA. We found decreasing of pain score in both group after surgery and less pain score in DMPA group. Key words: endometriosis, endometrioma, conservative surgery, IL-1α , DMPA