Incidence of Large-for-Gestational Age Newborn among Pregnant Women with One Abnormal Value Oral Glucose Tolerance Test

Abstract

Objectives To evaluate the incidence and risk factors of LGA newborn among pregnant women
with one abnormal value OGTT.
Design Retrospective cohort study.
Methods A total of 189 pregnant women who had one abnormal value OGTT were enrolled
and followed until delivery. Incidence of LGA was determined as the main outcome.
Comparison between LGA and non-LGA was performed with regard to various clinical
characteristics to determine associated risk factors. Pregnancy and neonatal outcomes
were also evaluated.
Results Incidence of LGA newborn was 19.05% (36/189 cases). The independent
associated factors of LGA newborn was multiparity (adjusted OR 5.3, 95%CI 1.2-23.2,
p=0.029) and excessive weight gain (adjusted OR 50.2, 95%CI 12.4-203.9, p <0.001). LGA
newborn had significant increased rate of cesarean section (83.3% vs 5.9%, p <0.001) and
neonatal hypoglycemia (5.6% vs 0%, p=0.035).
Conclusion Pregnant women with one abnormal value OGTT who were multiparous or had
excessive weight gain had a significant risk of LGA newborn.