Outcome of High-Risk Stage IA2 - IIA Cervical Cancer Treated with Radical Hysterectomy and Pelvic Lymphadenectomy

Abstract

Objective To evaluate the survival and complications of high-risk stage IA2 - IIA cervical cancer
treated with radical hysterectomy and pelvic lymphadenectomy.
Design Retrospective descriptive study.
Setting Division of Gynecologic oncology Department of Obstetrics and Gynecology, Faculty
of Medicine, Chiang Mai University.
Subject 156 patients with FIGO stage IA2 to IIA cervical cancer treated between January
1998 to January 2003, undergoing radical hysterectomy with pelvic lymphadenectomy and had
at least one high risk pathological factors.
Intervention Pelvic lymphadenectomy was initially performed followed by radical hysterectomy.
Patients with high risk pathological factors were treated with adjuvant radiation with or without
concurrent chemotherapy.
Result With median follow up of 26 months, the projected 5-year progression-free survival
and overall survival were 80.0% and 93.4% respectively. Treatment-related complication
occurred in 15 patients (9.6%), all of these patients received adjuvant radiation. The
incidences of lymph node metastasis and parametrial involvement were 18.8% and 11.2%
respectively. Tumor recurrence occurred in 12 patients (7.7%) in which 8 of these had lymph
node metastasis, the remaining had parametrial invasion.
Conclusion Stage IA2 - IIA cervical cancer patients with high-risk pathological factors had
relatively high survival rate with low complication in this setting.