Compliance with Hormone Replacement Therapy Among Natural Menopausal Women at The Menopause Clinic, Siriraj Hospital

Abstract

Objectives To determine the long-term compliance of HRT at a tertiary care menopause clinic
and evaluate factors associated with HRT compliance.
Design Descriptive study.
Setting Menopause clinic, Department of Obstetrics and Gynecology, Faculty of Medicine
Siriraj Hospital, Mahidol University.
Subjects A total of 400 natural menopausal women attending the menopause clinic and started
hormone replacement therapy during the year 1996 - 1998.
Main outcome measures Compliance with hormone replacement therapy.
Results Compliance with hormone replacement therapy at 1 and 2 years were 75.2% and
47.8% respectively. Age at menopause, age at initial HRT, and menopausal symptoms before
initial HRT were comparable between compliant and non-compliant groups. Non-compliant
group was significantly more likely to experience HRT side effects (p < 0.001)
Conclusion Compliance with hormone replacement therapy at 1 and 2 years were 75.2% and
47.8% respectively. The only significant factor associated with decreased compliance was having
side effects after using HRT.