Single Oral Dose Ibuprofen for Pain Relief in Fractional Curettage under Paracervical Block: A Double-Blind Randomized Controlled Trial

Abstract

Objective To compare the analgesic efficacy of a single oral dose ibuprofen administered prior
to fractional curettage under paracervical block with that of placebo in women undergoing
fractional curettage.
Design Double-blind, randomized controlled trial.
Setting Gynaecological Out-patient, Department of Obstetrics and Gynaecology, Ramathibodi
Hospital.
Intervention The women were randomized to receive either 400 mg ibuprofen (n=70) or
placebo(n=70) 30-60 minutes prior to fractional curettage. All women were curetted under
paracervical block with 1% lidocaine.
Main outcome measure The intensity of pain during and after the procedure measured by the visual
analog score.
Results The intensity of pain in ibuprofen group was not significant difference from the
placebo group over the course of the procedure (P>0.05). There were no serious adverse
effect from the procedure.
Conclusion Pre-emptive single oral dose ibuprofen for fractional curettage under paracervical
block did not relief pain during and after the procedure.