Prevalence of Chromosomal Abnormalities by Genetic Amniocentesis for Prenatal Diagnosis at Rajavithi Hospital : 1999-2002

Abstract

Objective To evaluate results of amniocentesis for prenatal diagnosis of chromosome abnormality at Rajavithi Hospital.

Study Design Retrospective descriptive study.

Setting                Perinatal unit, Department of Obstetrics and Gynecology, Rajavithi Hospital.

Subjects One thousand four hundred and six patients who had genetic amniocentesis at perinatal unit, Department of Obstetrics and Gynecology, Rajavithi Hospital from January 1, 1999 to December 31, 2002.

Methods Records of mothers who had genetic amniocentesis during 1 January 1999 to 31 December 2002 were reviewed. Records of abnormal chromosome in newborn and results of genetic amniocentesis at Rajavithi Hospital were analyzed.

Results               A total of 1,406 high risk pregnant women who underwent midtrimester genetic

amniocentesis at Rajavithi Hospital were studied during January 1, 1999 to December 31, 2002. The most common indication was elderly gravidarum. Abnormal chromosome were detected prenataly 35 (2.5%). Women with chromosome abnormalities fetus underwent termination of pregnancy 22 (62.9%). There were 21 (1.6%) spontaneous abortion in normal karyotyping. Cell culture failure was 25 (1.8%). The cell culture failure was significantly increased in pregnancies with blood-stained amniotic fluid (P < 0.001).

Conclusion Genetic amniocentesis were highly successful performed with low complication. It is a safe and reliable method in prenatal diagnosis of chromosome abnormalities.