Prolonged Stabilization of Advanced Fallopian Tube Cancer with Leuprolide Acetate

Abstract

Primary carcinoma of the fallopian tube is an uncommon gynaecologic malignancy
with no standard systemic therapy. However, it is usually treated in the same way as epithelial ovarian cancer. ln case of chemotherapy failure, hormonal therapy, such as tamoxifen or progesterone, may be used. The GnRH agonists, such as leuprolide acetate, have some activity in advanced platinum refractory ovarian cancer. We presented the case of a77-yearold woman with stage lV fallopian tube carcinoma. Her disease became resistant to platinum, tamoxifen, and sequentially administered estradiol and megestrol acetate. She was then treated with leuprolide acetate depot 7.5 mg intramuscular injection monthly. The disease was stabilized for 12 months. Therefore, leuprolide acetate may be considered for the treatment of patients with advanced fallopian tube cancer whose disease developed resistance to platinum based chemotherapy.