Risk factors associated with colistin-resistant gram-negative bacteria infection in Roi Et Hospital

Abstract

The objective of this case‐control study was to determine factors associated with colistin-resistant gram-negative bacteria infections among patients of the Roi‐Et hospital. The study was conducted between 1 July 2018 to 31 July 2021. 194 cases with colistin-resistant gram-negative bacteria infection and 388 controls without colistin-resistant gram-negative bacteria infections participated in the investigation. Descriptive and inference statistics used were the univariate analysis and multivariable analysis by multiple logistic regression.

            The average age of the cases was 60.35 years. Most of them were males (64.40 %). The average age of the controls was 62.86 years and 61.10 % were males. The duration of stay in hospital was 23.27 days for cases and 23.91 days for controls. Factors associated with colistin-resistant gram-negative bacteria infection, assessed by multiple logistic regression, included patient with co-morbidity (OR_adj = 2.77, 95%CI= 1.72 – 4.47), patient admitted more than 7 days (OR_adj = 2.56, 95%CI= 1.76 – 3.72) and patient on endotracheal tubes (OR_adj = 3.40, 95%CI= 2.20 – 5.25). Factors linked to treatment accounted for prior antibiotic treatment which ^{3rd -4th}Cephalosporins (OR_adj = 1.75; 95%CI = 1.19 – 2.57).

            In conclusion, thus the patient with those risk factors should be provided intensive medical and nursing guideline to control and prevent colistin-resistant gram-negative bacteria infection.