The treatment of Curcuma longa on rabbit dermatitis
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Abstract
Curcumin is one of the major components of Curcuma longa that has been reported to anti-inflammation, antioxidants, and anti-bacterial, especially Staphylococcus aureus. This study examines the anti-inflammatory and antioxidant effect of Curcumin against bacterial infection on rabbit skin. Fifteen rabbits were randomly divided into five groups as follows: un-infection and un-treatment with scarification, infection without treatment, treatments with 5% and 10% Curcuma longa creams and Tetracycline cream. Skin lesion of the rabbits was monitored for a week. The activities of antioxidant enzyme, level of total glutathione and lipid-peroxidation were examined to finally detect the oxidative stress. This study found that the activities of antioxidant systems and the level of lipid peroxidation was significantly reduced when we treated with Curcuma longa cream while level of total glutathione were gradually increased in skin rabbit. 10% Curcuma longa cream is the most effective. These findings imply that the effort of developing Curcumin into a therapeutic antibacterial skin and anti-resistant agent is reasonable.
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References
Al-Rubaei, Z.M., Mohammad, T.U., Ali, L.K. 2014. Effects of local curcumin on oxidative stress and total antioxidant capacity in vivo study. Pak. J. Biol. Sci. 17, 1237-1241.
Bessa, G.R., Quinto, V.P., Machado, D.C., Lipnharski, C., Weber, M.B., Bonamigo, R.R., D'Azevedo, P.A., 2016. Staphylococcus aureus resistance to topical antimicrobials in atopic dermatitis. An. Bras. Dermatol. 91, 604–610.
Cheng, G., Hao, H., Xie, S., Wang, X., Dai, M., Huang, L., Yuan, Z., 2014. Antibiotic alternatives: the substitution of antibiotics in animal husbandry? Front. Microbiol. 5, 217.
Curtis, S.K., 1991. Diagnostic exercise: moist dermatitis on the hind quarters of a rabbit. Lab. Anim. Sci. 41, 623-624.
Dai, T., Kharkwal, G.B., Tanaka, M., Huang, Y.Y., Bil de Arce, V.J., Hamblin, M.R., 2011. Animal models of external traumatic wound infections. Virulence. 2, 296-315.
Daverey, A., Agrawal, S.K. 2016. Curcumin alleviates oxidative stress and mitochondrial dysfunction in astrocytes. Neuroscience. Doi, 10.1016/j.neuroscience.2016.07.012.
Devi, G.S., Prasad, M.H., Saraswathi, I., Raghu, D., Rao, DN., Reddy PP. 2000. Free radicals antioxidant enzymes and lipid peroxidation in different types of leukemias. Clin. Chim. Acta. 293, 53-62.
Garibaldi, B.A., Fox, J.G., Musto, D.R., 1990. Atypical moist dermatitis in rabbits. Lab. Anim. Sci. 40, 652-653.
Gupta, A., Mahajan, S., Sharma, R., 2015. Evaluation of antimicrobial activity of Curcuma longa rhizome extract against Staphylococcus aureus. Biotechnol. Rep. (Amst). 6, 51-55.
Ji, H., Li, X.K. 2016. Oxidative Stress in Atopic Dermatitis. Oxid. Med. Cell. Longev. doi, 10.1155/2016/2721469.
Kobayashi, S.D., Malachowa, N., DeLeo, F.R., 2015. Pathogenesis of Staphylococcus aureus abscesses. Am. J. Pathol. 185, 1518–1527.
Kupper, T.S., Fuhlbrigge, R.C., 2004. Immune surveillance in the skin: Mechanisms and clinical consequences. Nat. Rev. Immunol. 4, 211–222.
Malachowa, N., Kobayashi, S.D., Porter, A.R., Braughton, K.R., Scott, D.P., Gardner, D.J., Missiakas, D.M., Schneewind, O., DeLeo, F.R., 2016. Contribution of Staphylococcus aureus Coagulases and Clumping Factor A to Abscess Formation in a Rabbit Model of Skin and Soft Tissue Infection. PLoS One. 11(6):e0158293.
Mapara, M., Thomas, B.S., Bhat, K.M., 2012. Rabbit as an animal model for experimental research. Dent. Res. J. (Isfahan). 9, 111–118.
Charinya et al., Chiang Mai Veterinary Journal 2018; 16(1): 1-13 13
Meulemans, L., Hermans, K., Duchateau, L., Haesebrouck, F., 2007. High and low virulence Staphylococcus aureus strains in a rabbit skin infection model. Vet. Microbiol. 125, 333-340.
Montgomery, C.P., Daniels, M.D., Zhao, F., Spellberg, B., Chong, A.S., Daum, R.S., 2013. Local inflammation exacerbates the severity of Staphylococcus aureus skin infection. PLoS One. 8(7):e69508.
Nestle, F.O., Di Meglio, P., Qin, J.Z., Nickoloff, B.J., 2009. Skin immune sentinels in health and disease. Nat. Rev. Immunol. 9, 679–691.
Pimson, C., Chatuphonprasert, W., Jarukamjorn, K., 2014. Improvement of antioxidant balance in diabetes mellitus type 1 mice by glutathione supplement. Pak. J. Pharm. Sci. 27, 1731-1737.
Prabhakara, R., Foreman, O., De Pascalis, R., Lee, G.M., Plaut, R.D., Kim, S.Y., Stibitz, S., Elkins, K.L., Merkel, T.J., 2013. Epicutaneous model of community-acquired Staphylococcus aureus skin infections. Infect. Immun. 81, 1306-1315.
Rai, D., Singh, J.K., Roy, N., Panda, D., 2008. Curcumin inhibits FtsZ assembly: an attractive mechanism for its antibacterial activity. Biochem. J. 410, 147-155.
Rayner, C., Munckhof, W.J., 2005. Antibiotics currently used in the treatment of infections caused by Staphylococcus aureus. Intern. Med. J. 35, S3-S16.
Sunderkötter, C., Becker, K., 2015. Frequent bacterial skin and soft tissue infections: diagnostic signs and treatment. J. Dtsch. Dermatol. Ges. 13, 501-524.
Swindle, E.J., Brown, J.M. Rådinger, M., DeLeo, F.R., Metcalfe, D.D., 2015. Interferon-γ enhances both the anti-bacterial and the pro-inflammatory response of human mast cells to Staphylococcus aureus. Immunology. 146, 470– 485.
Teow, S.Y., Liew, K., Ali, S.A., Khoo, A.S.B., Peh, S.C., 2016. Antibacterial Action of Curcumin against Staphylococcus aureus: A Brief Review. J. Trop. Med. 2016, 2853045.
Tyagi, P., Singh, M., Kumari, H., Kumari, A., Mukhopadhyay, K., 2015. Bactericidal activity of curcumin I is associated with damaging of bacterial membrane. PLoS One. 10, e0121313.