Histiocytic sarcoma in dogs
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Published:
Aug 21, 2018
Keywords:
Dog Histiocytic sarcoma Immunohistochemistry Treatment
Main Article Content
Abstract
Canine histiocytic sarcoma (CHS), also known as malignant histiocytosis is a very aggressive hematologic malignancy that has a high metastatic rate and mortality rate. CHS originates from white blood cells, namely histiocytes that commonly reside in soft tissue and connective tissue throughout the body. Microscopically, the cell morphology of this tumor sometimes
is indistinguishable from other round cell tumors and carcinomas by using routine hematoxylin and eosin staining. Currently, immunohistochemistry is a valuable diagnostic tool for identifying types and cell of origin of the tumor that most CHS cells have dendritic cell immunophenotype (CD18+, CD11c+, MHCII+, CD11d-). The most currently available treatments
for CHS are the combination of surgical excision, radiotherapy and chemotherapy, known as multimodal therapy, in order to increase treatment efficacy and survival time of dogs with CHS. Furthermore, the palliative treatment should be considered in CHS cases to improve the quality of life.
Article Details
How to Cite
Thongtharb, A. (2018). Histiocytic sarcoma in dogs. Veterinary Integrative Sciences, 16(2), 19–34. Retrieved from https://he02.tci-thaijo.org/index.php/vis/article/view/141477
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Review Article
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Gaspar, T.B., Henriques, J., Marconato, L., Queiroga, F.L., 2018. The use of low-dose metronomic chemotherapy in dogs-insight into a modern cancer field. Vet Comp Oncol. 16, 2 - 11.
Hafeman, S., London, C., Elmslie, R., Dow, S., 2010. Evaluation of liposomal clodronate for treatment of malignant histiocytosis in dogs. Cancer Immunol Immunother. 59, 441 - 452.
Hafeman, S.D., Varland, D., Dow, S.W., 2012. Bisphosphonates significantly increase the activity of doxorubicin or vincristine against canine malignant histiocytosis cells. Vet Comp Oncol. 10, 44 - 56.
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