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Porcine Reproductive and Respiratory Syndrome (PRRS) caused by PRRS virus is an important viral infectious disease of swine that causes immense economic loss in swine industries worldwide. Presently, the defensive and controls of PRRS outbreak are mostly depend on the farm biosecurity, gilt management and successive vaccination program. However, the disease control by those strategies remained uncertain and unpredictable. Therefore, seeking an alternative antiviral compound for preventing and controlling PRRS is of great interest. In the present study, we aim to investigate the anti-PRRSv property of the curcuma, compound derived from medicinal plant in Zingiberaceae family. Turmeric extraction (curcuminoids) was obtained and was increase dissolved by the solid dispersion technique and found that at the concentration of 0.00005 – 1.56 µg/mL showed no cytotoxicity effect on the MARC-145 cells. Interestingly, at the concentration of 1.56 µg/mL, curcuminoids showed significantly inhibit PRRS virus replication. This result is interesting in use herb extraction against PRRS infection and should be study, in vivo
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